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Blockers

Voltage-Gated Na+ Channels

Blockers

Voltage-gated Na­­­­­­­+ (NaV) channels are important for the generation and propagation of signals in electrically excitable tissues like the muscle, heart, and nerve. Activation of these channels ultimately leads to muscular contraction, cardiac rhythm, and neuronal firing. Nine mammalian isoforms of voltage-gated Na­­­­­­­+ channels have been identified (NaV1.1-NaV1.9). Nine genes (SCN1A, SCN2A, etc.) encoding distinct α subunit isoforms and 4 β subunit genes (SCN1B, SCN2B, etc.) have been identified in the human genome. The nine isoforms share a similar (but complex) architecture.

Displaying 1 to 20 (out of 94 products)
  • 4,9-Anhydrotetrodotoxin

    A Potent and Selective Blocker of NaV1.6 Channel

    Cat # T-560
    Source Synthetic
    MW 301.25
    Target NaV1.6 channel
    • Bioassay Tested
  • α-Asarone

    An Antagonist of NaV Channels, GABA(A) Receptors, NMDA Receptors and an Inhibitor of TrkB Receptor

    Cat # A-260
    Source Natural
    MW 208.3
    Target NaV channels, GABA(A) receptors, TrkB receptors, NMDA receptors
    • Bioassay Tested
  • µ-Conotoxin BuIIIA

    A Selective and Potent Blocker of NaV1.2 and NaV1.4 Channels

    Cat # STC-540
    MW 2752 Da.
    Target NaV1.2, NaV1.4 channels
    • Bioassay Tested
  • µ-Conotoxin BuIIIB

    A Blocker of NaV1.4 and NaV1.3 and NaV1.2 Na+ Channels

    Cat # STC-661
    MW 2764 Da.
    Target NaV1.2, NaV1.3 and NaV1.4 Na+ channels
    • Bioassay Tested
  • µ-Conotoxin BuIIIC

    A Blocker of NaV1.4 Channel 

    Cat # STC-690
    MW 3006 Da.
    Target NaV1.4 Na+ channels
    • Bioassay Tested
  • µ-Conotoxin CnIIIC

    A Blocker of NaV Channels and an Antagonist of nAChRs

    Cat # STC-640
    MW 2376 Da.
    Target NaV Na+ channels, α3/β2 nAChR
    • Bioassay Tested
  • µ-Conotoxin GIIIA

    A Blocker of NaV1.4 Na+ Channel 

    Cat # STC-280
    MW 2609 Da.
    Target NaV1.4 Na+ channel
    • Bioassay Tested
  • µ-Conotoxin GIIIB

    A Selective Blocker of Skeletal Muscle NaV1.4 Channels

    Cat # C-270
    MW 2640 Da.
    Target NaV1.4 Na+ channels
    • Bioassay Tested
  • µ-Conotoxin KIIIA

    A Potent Blocker of Mammalian TTX-Sensitive NaV1 Channels

    Cat # C-280
    MW 1883 Da.
    Target TTX-sensitive Na+ channels
    • Bioassay Tested
  • µ-Conotoxin PIIIA

    A Potent Blocker of NaV1.2, NaV1.4 and NaV1.7 Na+ Channels

    Cat # STC-400
    MW 2604 Da.
    Target Various Nachannels
    • Bioassay Tested
  • µ-Conotoxin SIIIA

    A Blocker of TTX-Sensitive NaV1.2, NaV1.3 and NaV1.4 Voltage-Gated Na+ Channels

    Cat # STC-450
    MW 2207 Da.
    Target NaV1.2, NaV1.3, NaV1.4 Na+ channels
    • Bioassay Tested
  • µ-Conotoxin SxIIIA

    A Blocker of NaV1.4 Channels

    Cat # STC-645
    MW 2271 Da.
    Target NaV1.4 Na+ channels
    • Bioassay Tested
  • A-803467

    A Potent and Selective Blocker of the TTX-Resistant NaV1.8 Channel

    Cat # A-105
    Source Synthetic
    MW 357.8
    Target NaV1.8 Na+ channels
    • Bioassay Tested
  • BDS-I

    A Blocker of KV3 Channels and a Modulator of NaV Channels

    Cat # STB-400
    MW 4708 Da.
    Target KV3 K+ channels, NaV Na+ channels
    • Bioassay Tested
  • BDS-II

    A Blocker of KV3 Channels and a Modulator of NaV Channels

    Cat # B-450
    MW 4776 Da.
    Target KV3 K+ channels, NaV Na+ channels
    • Bioassay Tested
  • Ceratotoxin-1

    A Blocker of NaV channels

    Cat # STC-680
    MW 4044 Da.
    Target NaV channels
    • Bioassay Tested
  • Ceratotoxin-2

    A Potent Blocker of Central Nervous System Voltage-Gated Na+ Channels

    Cat # STC-100
    MW 4093 Da.
    Target NaV channels
    • Bioassay Tested

* See product page

Displaying 1 to 20 (out of 94 products)