Extracellular antibodies are ideal research tools for cell-surface proteins.
No permeabilization/fixation because using extracellular antibodies allows you to work with live cells!
Benefits of live cell imaging:
✓ Monitor cell movement
✓ Study protein transport across the cell
✓ Investigate protein internalization
CaV2.1 makes up the α1 pore-forming subunit in the P/Q-type Ca2+ channel family. It is primarily expressed in the central nervous system where it is partly responsible for pre-synaptic Ca2+ influx and neurotransmitter release.