CNGA Antibody Explorer Kit

A Screening Package of CNGA Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-204
Sizes: 8 Vials
Last update: 23/04/2019

Alomone Labs is pleased to offer the CNGA Antibody Explorer Kit (#AK-204). This Explorer Kit includes antibodies targeted against CNGAs along with their respective peptide control antigen. An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-CNGA1 Antibody
APC-071 1 x 50 µl
Anti-CNGA2 Antibody
APC-045 1 x 50 µl
Anti-CNGA3 Antibody
APC-060 1 x 50 µl
Anti-CNGA4 Antibody
APC-074 1 x 50 µl
Scientific Background
    • Cyclic nucleotide-gated (CNG) channels belong to the superfamily of voltage-gated ion channels. Although permeable to various ions such as the monovalent Na+ and K+ ions, and the divalent Ca2+ ion, they are gated by the intracellular binding of the cyclic nucleotides cAMP and cGMP and not by voltage per se (CNGs bind preferably to cGMP)1.

      Six channels form this subfamily: The A subunit (CNGA1-4) and the B subunit (CNGB1 and CNGB3). Functional entities are formed by the assembly of four subunits. Each subunit consists of six membrane spanning domains, where the fourth transmembrane domain is highly positively charged, a pore domain between transmembrane domains five and six, and intracellular N- and C-termini. The cyclic nucleotide binding domain is located in the C-terminal region and is responsible for the channel gating upon cyclic nucleotide binding1.

      These channels are highly expressed in retinal photoreceptors and olfactory neurons where their role has been extensively studied2. CNG channels have also been detected in brain, testis and kidney although their role in these tissues has yet to be unraveled2.

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