Proteins

Glial-Derived Neurotrophic Factor (GDNF) Family

Proteins

The GDNF family ligands (GFLs) belong to the super family of the TGF-β. They belong to the group of cystine-knot protein and function as homodimers. This family includes glial cell line-derived neurotrophic factor (GDNF), artemin (ARTN), Neurturin (NRTN) and persephin (PSPN). These factors are heavily involved in the development and function of the nervous system (both central and peripheral). In general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor α (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret.

Displaying 1 to 5 products (out of 5 products)
  • Recombinant human Artemin protein

    Human Artemin, Recombinant, E. coli

    Cat # RPA-100
    Source Recombinant, E. coli
    MW 24 kDa, Dimer.
    • Lyophilized Powder
    • Sterile & Endotoxin Free
  • Recombinant human GDNF protein

    Human Glial-Derived Neurotrophic Factor, Recombinant, E. coli

    Cat # G-240
    Source Recombinant, E. coli
    MW 30.1 kDa.
    • Lyophilized Powder
    • Sterile & Endotoxin Free
  • human GDNF proDomain

    Human Glial-Derived Neurotrophic Factor proDomain, Synthetic

    Cat # SPG-100
    Source Synthetic peptide
    MW 6334 Da.
    • Lyophilized Powder
    • Sterile & Endotoxin Free
  • Human GFRα1-Fc Chimera

    An Inhibitor of GDNF Activity

    Cat # RPC-003
    Source Recombinant protein
    MW ~ 85 kDa.
    Target GDNF
    • Lyophilized Powder
    • Sterile & Endotoxin Free
  • Recombinant human Persephin protein

    Human Persephin, Recombinant, E. coli

    Cat # P-320
    Source Recombinant, E. coli
    MW 20.6 kDa.
    • Lyophilized Powder
    • Sterile & Endotoxin Free

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Displaying 1 to 5 products (out of 5 products)