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Transmembrane Channel-Like Proteins (TMC)

EVER gene belongs to larger family of proteins referred to as the transmembrane channel-like protein (TMC) family. EVER1/TMC6 protein, integral membrane protein, is located in the endoplasmic reticulum (ER) of keratinocytes, where it forms a complex with zinc transporter-1 (ZnT-1) a membrane protein responsible for zinc efflux and resistance to zinc toxicity, thereby controlling the cellular zinc balance. The EVER1 protein is predicted to have 10 transmembrane domains and 2 leucine zipper motifs.

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