KCa1.1 Channel Modulator Explorer Kit

A Screening Package of KCa1.1 Channel Modulators Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: EK-132
Sizes: 13 Vials
Last update: 03/10/2018

Alomone Labs is pleased to offer the KCa1.1 Channel Modulator Explorer Kit (#EK-132). The Explorer Kit contains KCa1.1 blockers and openers ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Charybdotoxin
STC-325 1 x 0.1 mg
Kaliotoxin-1
STK-370 1 x 50 µg
Iberiotoxin
STI-400 1 x 0.1 mg
Isopimaric Acid
I-370 1 x 1 mg
NS-11021
N-335 1 x 5 mg
NS-1619
N-105 1 x 5 mg
NS19504
N-235 1 x 5 mg
Paxilline
P-450 1 x 0.45 mg
Penitrem A
P-650 1 x 0.65 mg
Pimaric Acid
P-270 1 x 1 mg
Slotoxin
RTS-410 1 x 5 µg
Tanshinone II-A sodium sulfonate
T-165 1 x 5 mg
Verruculogen
V-500 1 x 0.51 mg
References
Scientific Background

The KCa1.1 channel (also known as BKCa, Maxi K+ or slo) is part of a structurally diverse group of K+ channels that are activated by an increase in intracellular Ca2+. KCa1.1 shows a large single channel conductance when recorded electrophysiologically, hence its name. It differs from the rest of the subfamily members in that it can be activated by both an increase in intracellular Ca2+ and by membrane depolarization. In addition, the KCa1.1 channel structurally differs from the other Ca2+-dependent K+ channels. While the latter group has a topology that resembles that of the voltage-dependent K+ channels, the KCa1.1 channel has an extracellular N-terminus domain as well as an additional transmembrane domain.

KCa1.1 is expressed in virtually all cell types where it causes hyperpolarization and helps to bridge intracellular Ca2+ signaling pathways and membrane excitability.

Indeed, KCa1.1 channels play a crucial role in smooth muscle contractility, neuronal spike shaping and neurotransmitter release.

References
  1. Orio, P. et al. (2002) News Physiol. Sci. 17, 156.
  2. Wallner, M. et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 4137.
  3. Xia, X.M. et al. (1999) J. Neurosci. 19, 5255.
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