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Two Pore Ca2+ Channels

Among various vertebrate species, three genes are known to encode two-pore segment channels (TPCs) termed TPC1-3. Interestingly TPC3 seems to be absent from the genomes of primates and rodents. The primary sequence of these channels indicates the presence of two putative pore-forming repeats. Each repeat contains six transmembrane domains and a pore loop, a structure strikingly reminiscent of many voltage-gated Na+ (NaV) and Ca2+ (CaV) channels. These twelve transmembrane structures are further thought to form functional dimers.

  • Lysosomal Ion Channel Antibody Explorer Kit

    A Screening Package of Lysosomal Ion Channel Antibodies Economically Priced

    Cat # AK-530
  • Anti-TPCN1 Antibody

    A Rabbit Polyclonal Antibody to Two Pore Calcium Channel Protein 1

    Cat # ACC-071
    Type Polyclonal
    Host Rabbit
    Applications ihc, wb, icc*, ifc*, ip*
    Reactivity h, m, r
  • Anti-TPCN2 Antibody

    A Rabbit Polyclonal Antibody to Two Pore Calcium Channel Protein 2

    Cat # ACC-072
    Type Polyclonal
    Host Rabbit
    Applications if, ihc, wb, icc*, ifc*, ip*
    Reactivity h, m, r
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