BKCa Channel Antibody Explorer Kit

A Screening Package of BKCa Channel Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-217
Sizes: 20 Vials
Last update: 23/04/2019

Alomone Labs is pleased to offer the BKCa Channel Antibody Explorer Kit (#AK-217). This Explorer Kit includes antibodies targeted against BKCa channels and auxiliary subunits along with their respective peptide control antigen. An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Note A guinea pig polyclonal antibody (#AGP-014) is included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

The KCa1.1 channel (also known as BKCa, Maxi K+ or slo) is part of a structurally diverse group of K+ channels that are activated by an increase in intracellular Ca2+. KCa1.1 shows a large single channel conductance when recorded electrophysiologically and hence its name. It differs from the rest of the subfamily members in that it can be activated by both an increase in intracellular Ca2+ and by membrane depolarization.  In addition, the KCa1.1 channel structurally differs from the other Ca2+-dependent K+ channels.

While the latter group has a topology that resembles that of the voltage-dependent K+ channels, the KCa1.1 channel has an extracellular N-terminus domain as well as an additional transmembrane domain.

KCa1.1 is expressed in virtually all cell types where it causes hyperpolarization and helps to connect between intracellular Ca2+ signaling pathways and membrane excitability.
 
Indeed, KCa1.1 channels play a crucial role in smooth muscle contractility, neuronal spike shaping and neurotransmitter release.

References
  1. Nelson, M.T. et al. (1995) Am J. Physiol. 268, C799.
  2. Toro, L. et al. (1998) News Physiol. Sci13, 112.
  3. Lu, R. et al. (2006) J. Physiol. 570, 65.
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