Ion Channels

Ion Channels

Engineered venom-derived peptide toxins designed for high-specificity ion channel research and reproducible experimental performance.

Our toxins are developed in-house using controlled synthesis, folding, and multistep purification workflows that eliminate non-specific components found in crude venom. Each peptide is validated by HPLC, mass spectrometry, and functional bioassays, for lot-to-lot consistency and reliable performance. Available in synthetic, recombinant, native, and optionally fluorophore-conjugated formats. These reagents enable precise functional electrophysiology, imaging, and live-cell studies across neuronal systems.

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FAQs

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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Category: α7
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13 Results
  • α-Bungarotoxin
    Bioassay Tested
    α-Bungarotoxin
    A potent antagonist of muscle nAChRs, α7 nAChRs, and GABA(A) receptor subtypes
    • Product Code: B-100
    • Applications: Electrophysiology
    • CAS No.: 11032-79-4
    • MW: 7984 Da
  • α-Bungarotoxin-ATTO Fluor-647N
    Bioassay Tested
    α-Bungarotoxin-ATTO Fluor-647N
    A fluorescent probe for imaging and sensitive detection of neuromuscular junctions, GABA(A) receptors, nAChRs, and α-Bungarotoxin binding sites
    • Product Code: B-100-FRN
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: ~8925 Da
  • α-Bungarotoxin-ATTO Fluor-590
    Bioassay Tested
    α-Bungarotoxin-ATTO Fluor-590
    A fluorescent probe for imaging and sensitive detection of neuromuscular junctions, GABA(A) receptors, nAChRs, and α-Bungarotoxin binding sites
    • Product Code: B-100-AR
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: ~9131 Da
  • α-Conotoxin ImI-ATTO Fluor-590
    Bioassay Tested
    α-Conotoxin ImI-ATTO Fluor-590
    A fluorescent probe for imaging and sensitive detection of α3β2 and α7 nicotinic acetylcholine receptors (nAChR)
    • Product Code: C-290-AR
    • Short Description: A fluorescent probe for imaging and sensitive detection of α3β2 and α7 nicotinic acetylcholine receptors (nAChR)
    • Applications: Electrophysiology, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: 1924 Da
  • α-Bungarotoxin-FITC
    Bioassay Tested
    α-Bungarotoxin-FITC
    A fluorescent probe for imaging and sensitive detection of neuromuscular junctions, GABA(A) receptors, nAChRs, and α-Bungarotoxin binding sites
    • Product Code: B-100-F
    • Applications: Electrophysiology, Fluorescence staining
    • MW: ~8406 Da
  • α-Bungarotoxin-Biotin
    Bioassay Tested
    α-Bungarotoxin-Biotin
    A biotinylated probe for imaging and sensitive detection of neuromuscular junctions, GABA(A) receptors, nAChRs, and α-Bungarotoxin binding sites
    • Product Code: B-100-B
    • Applications: Electrophysiology, Immunofluorescence, Indirect flow cytometry
    • MW: ~9030 Da
  • α-Conotoxin Vc1.1
    Bioassay Tested
    α-Conotoxin Vc1.1
    A potent antagonist of α9α10 nAChRs and agonist of GABA(B) receptors
    • Product Code: STV-500
    • Short Description: A potent antagonist of α9α10 nAChRs and agonist of GABA(B) receptors
    • Applications: Electrophysiology
    • CAS No.: 740980-24-9
    • MW: 1807 Da
  • α-Conotoxin MrIC
    Bioassay Tested
    α-Conotoxin MrIC
    An α7 nAChR potent antagonist that functions as a PAM-dependent biased agonist
    • Product Code: STC-320
    • Short Description: An α7 nAChR potent antagonist that functions as a PAM-dependent biased agonist
    • Applications: Electrophysiology
    • MW: 1835 Da
  • α-Conotoxin RgIA
    Bioassay Tested
    α-Conotoxin RgIA
    A potent antagonist of α9α10 nAChRs that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-010
    • Short Description: A potent antagonist of α9α10 nAChRs that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • MW: 1571 Da
  • α-Conotoxin ImI
    Bioassay Tested
    α-Conotoxin ImI
    A potent antagonist of the neuronal α3β2 and α7 nicotinic acetylcholine receptors (nAChR)
    • Product Code: C-290
    • Short Description: A potent antagonist of the neuronal α3β2 and α7 nicotinic acetylcholine receptors (nAChR)
    • Applications: Electrophysiology
    • CAS No.: 156467-85-5
    • MW: 1351 Da
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