Ion Channels

Ion Channels

Engineered venom-derived peptide toxins designed for high-specificity ion channel research and reproducible experimental performance.

Our toxins are developed in-house using controlled synthesis, folding, and multistep purification workflows that eliminate non-specific components found in crude venom. Each peptide is validated by HPLC, mass spectrometry, and functional bioassays, for lot-to-lot consistency and reliable performance. Available in synthetic, recombinant, native, and optionally fluorophore-conjugated formats. These reagents enable precise functional electrophysiology, imaging, and live-cell studies across neuronal systems.

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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Category: α3β4
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8 Results
  • α-Conotoxin Vc1.1
    Bioassay Tested
    α-Conotoxin Vc1.1
    A potent antagonist of α9α10 nAChRs and agonist of GABA(B) receptors
    • Product Code: STV-500
    • Short Description: A potent antagonist of α9α10 nAChRs and agonist of GABA(B) receptors
    • Applications: Electrophysiology
    • CAS No.: 740980-24-9
    • MW: 1807 Da
  • α-Conotoxin PeIA
    Bioassay Tested
    α-Conotoxin PeIA
    An antagonist of neuronal nAChRs (α9α10, α6-containing, and α3/β2) that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-970
    • Applications: Electrophysiology
    • CAS No.: 866876-88-2
    • MW: 1652 Da
  • α-Conotoxin AuIA
    Bioassay Tested
    α-Conotoxin AuIA
    A selective antagonist of the neuronal α3/β4 nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-960
    • Short Description: A selective antagonist of the neuronal α3/β4 nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 216299-20-6
    • MW: 1726 Da
  • α-Conotoxin AuIB
    Bioassay Tested
    α-Conotoxin AuIB
    An antagonist of mammalian α3/β4 neuronal nAChR that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-310
    • Short Description: An antagonist of mammalian α3/β4 neuronal nAChR that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • CAS No.: 216299-21-7
    • MW: 1572.8 Da
  • α-Conotoxin TxID
    Bioassay Tested
    α-Conotoxin TxID
    A potent antagonist of α3β4 nAChRs that also inhibits α6/α3β4 nicotinic acetylcholine receptors
    • Product Code: STC-110
    • Short Description: A potent antagonist of α3β4 nAChRs that also inhibits α6/α3β4 nicotinic acetylcholine receptors
    • Applications: Electrophysiology
    • CAS No.: 1496617-64-1
    • MW: 1489.8 Da
  • α-Conotoxin GIC
    Bioassay Tested
    α-Conotoxin GIC
    A potent and selective antagonist of α3β2 and α6-containing nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-070
    • Short Description: A potent and selective antagonist of α3β2 and α6-containing nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1609.8 Da
  • α-Conotoxin BuIA
    Bioassay Tested
    α-Conotoxin BuIA
    A broad-spectrum nAChR antagonist used to kinetically distinguish between β2- and β4-containing receptors
    • Product Code: STC-030
    • Short Description: A broad-spectrum nAChR antagonist used to kinetically distinguish between β2- and β4-containing receptors
    • Applications: Electrophysiology
    • MW: 1311.6 Da
  • κ-Bungarotoxin
    Bioassay Tested
    κ-Bungarotoxin
    A potent antagonist of α3-containing neuronal nicotinic acetylcholine receptors (nAChRs)
    • Product Code: B-300
    • Short Description: A potent antagonist of α3-containing neuronal nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 7265 Da
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