Ion Channels

Ion Channels

Engineered venom-derived peptide toxins designed for high-specificity ion channel research and reproducible experimental performance.

Our toxins are developed in-house using controlled synthesis, folding, and multistep purification workflows that eliminate non-specific components found in crude venom. Each peptide is validated by HPLC, mass spectrometry, and functional bioassays, for lot-to-lot consistency and reliable performance. Available in synthetic, recombinant, native, and optionally fluorophore-conjugated formats. These reagents enable precise functional electrophysiology, imaging, and live-cell studies across neuronal systems.

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

Category: Caᵥ2.2 (N-type)
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31 Results
  • ω-Conotoxin MVIIC-ATTO Fluor 647N
    Bioassay Tested
    ω-Conotoxin MVIIC-ATTO Fluor 647N
    A fluorescent probe for imaging and sensitive detection of N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels in neurons
    • Product Code: C-150-FRN
    • Short Description: A fluorescent probe for imaging and sensitive detection of N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels in neurons
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: 3376 Da
  • α-Conotoxin Vc1.1
    Bioassay Tested
    α-Conotoxin Vc1.1
    A potent antagonist of α9α10 nAChRs and agonist of GABA(B) receptors
    • Product Code: STV-500
    • Short Description: A potent antagonist of α9α10 nAChRs and agonist of GABA(B) receptors
    • Applications: Electrophysiology
    • CAS No.: 740980-24-9
    • MW: 1807 Da
  • Kurtoxin
    Bioassay Tested
    Kurtoxin
    A blocker/gating modifier of multiple neuronal calcium channels
    • Product Code: STK-800
    • Short Description: A blocker/gating modifier of multiple neuronal calcium channels
    • Applications: Electrophysiology
    • CAS No.: 820959-57-7
    • MW: 7386.5 Da
  • Huwentoxin-XVI
    Bioassay Tested
    Huwentoxin-XVI
    A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Product Code: STH-105
    • Short Description: A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • CAS No.: 1600543-88-1
    • MW: 4437 Da
  • Huwentoxin-I
    Bioassay Tested
    Huwentoxin-I
    A presynaptic blocker of N-type (CaV2.2) calcium channels, TTX-sensitive (NaV) sodium, and muscle nAChR channels
    • Product Code: STH-050
    • Applications: Electrophysiology
    • MW: 3750 Da
  • ω-Grammotoxin SIA
    Bioassay Tested
    ω-Grammotoxin SIA
    A potent blocker of N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels
    • Product Code: STG-450
    • Short Description: A potent blocker of N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels
    • Applications: Electrophysiology
    • CAS No.: 152617-90-8
    • MW: 4109.8 Da
  • α-Conotoxin PeIA
    Bioassay Tested
    α-Conotoxin PeIA
    An antagonist of neuronal nAChRs (α9α10, α6-containing, and α3/β2) that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-970
    • Applications: Electrophysiology
    • CAS No.: 866876-88-2
    • MW: 1652 Da
  • ω-Conotoxin RVIA
    Bioassay Tested
    ω-Conotoxin RVIA
    A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Product Code: STC-850
    • Short Description: A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 2913.3 Da
  • ω-Conotoxin CnVIIA
    Bioassay Tested
    ω-Conotoxin CnVIIA
    A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Product Code: STC-800
    • Short Description: A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • CAS No.: 760212-36-0
    • MW: 2848.3 Da
  • ω-Conotoxin FVIA
    Bioassay Tested
    ω-Conotoxin FVIA
    A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Product Code: STC-780
    • Short Description: A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 2567 Da
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