Ion Channels

Ion Channels

Engineered venom-derived peptide toxins designed for high-specificity ion channel research and reproducible experimental performance.

Our toxins are developed in-house using controlled synthesis, folding, and multistep purification workflows that eliminate non-specific components found in crude venom. Each peptide is validated by HPLC, mass spectrometry, and functional bioassays, for lot-to-lot consistency and reliable performance. Available in synthetic, recombinant, native, and optionally fluorophore-conjugated formats. These reagents enable precise functional electrophysiology, imaging, and live-cell studies across neuronal systems.

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

Category: Kᵥ11.1 (hERG)
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8 Results
  • Haplotoxin-2
    Bioassay Tested
    Haplotoxin-2
    A blocker of NaV1.3 Na+ channel and KV11.1 (hERG) K+ channel
    • Product Code: STT-200
    • Short Description: A blocker of NaV1.3 Na+ channel and KV11.1 (hERG) K+ channel
    • Applications: Electrophysiology
    • MW: 3708.4 Da
  • HsTX1[R14A]
    Bioassay Tested
    HsTX1[R14A]
    A potent and selective blocker of KV1.3 K+ channels
    • Product Code: STH-310
    • Short Description: A potent and selective blocker of KV1.3 K+ channels
    • Applications: Electrophysiology
    • MW: 3733.4 Da
  • HsTx1 Toxin
    Bioassay Tested
    HsTx1 Toxin
    A potent blocker of KV1.3 K+ channels
    • Product Code: STH-300
    • Short Description: A potent blocker of KV1.3 K+ channels
    • Applications: Electrophysiology
    • MW: 3818.5 Da
  • GsAF-II
    Bioassay Tested
    GsAF-II
    A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Product Code: STG-350
    • Short Description: A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Applications: Electrophysiology
    • MW: 3979.8 Da
  • GsAF-I
    Bioassay Tested
    GsAF-I
    A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Product Code: STG-300
    • Short Description: A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Applications: Electrophysiology
    • MW: 3707.5 Da
  • GrTx1
    Bioassay Tested
    GrTx1
    A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Product Code: STG-250
    • Short Description: A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Applications: Electrophysiology
    • MW: 3697.5 Da
  • Ergtoxin-1
    Bioassay Tested
    Ergtoxin-1
    A potent and selective blocker of hERG (KV11.1) potassium channels
    • Product Code: STE-450
    • Short Description: A potent and selective blocker of hERG (KV11.1) potassium channels
    • Applications: Electrophysiology
    • CAS No.: 8006-25-5
    • MW: 4730 Da
  • BeKm-1
    Bioassay Tested
    BeKm-1
    A potent and selective blocker of hERG (KV11.1) potassium channels
    • Product Code: STB-470
    • Short Description: A potent and selective blocker of hERG (KV11.1) potassium channels
    • Applications: Electrophysiology
    • CAS No.: 524962-01-4
    • MW: 4092 Da
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