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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

Category: Neural Signaling
Category: Neurotrophin Co-Receptors
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13 Results
  • Taipoxin
    Bioassay Tested
    Taipoxin
    A blocker of synaptic vesicle recycling
    • Product Code: T-460
    • Short Description: A blocker of synaptic vesicle recycling
    • Applications: Neurite outgrowth assay, Immunocytochemistry
    • CAS No.: 52019-39-3
    • MW: 46 kDa
  • Tetanus Toxin
    Tetanus Toxin
    An inhibitor of neurotransmitter release
    • Product Code: T-150
    • Short Description: An inhibitor of neurotransmitter release
    • Applications: Cell-Based Assays, Synaptic Transmission Assays, Western blot
    • CAS No.: 676570-37-9
    • MW: 150 kDa
  • Muscarinic Toxin 7
    Bioassay Tested
    Muscarinic Toxin 7
    A negative allosteric modulator (NAM) of the M1 Muscarinic Receptor
    • Product Code: STM-200
    • Short Description: A negative allosteric modulator (NAM) of the M1 Muscarinic Receptor
    • Applications: Electrophysiology
    • CAS No.: 135541-77-4
    • MW: 7472.5 Da
  • Chlorotoxin
    Chlorotoxin
    A potent scorpion toxin that preferentially binds to tumor cells by targeting multiple receptors including chloride channels,MMP-2, and Neuropilin-1
    • Product Code: STC-460
    • Applications: Cell-Based Assays, Electrophysiology, Calcium imaging assay
    • CAS No.: 163515-35-3
    • MW: 3995.8 Da
  • Chlorotoxin
    Bioassay Tested
    Chlorotoxin
    A potent scorpion toxin that preferentially binds to tumor cells by targeting multiple receptors including chloride channels,MMP-2, and Neuropilin-1
    • Product Code: RTC-450
    • Applications: Cell-Based Assays, Electrophysiology, Calcium imaging assay
    • CAS No.: 163515-35-3
    • MW: 3996.7 Da
  • Pardaxin
    Pardaxin
    A channel-forming neurotoxin (ionophore) that induces neurotransmitter release through both calcium-dependent and calcium-independent mechanisms
    • Product Code: P-300
    • Short Description: A channel-forming neurotoxin (ionophore) that induces neurotransmitter release through both calcium-dependent and calcium-independent mechanisms
    • Applications: Membrane Permeability Assays, Vesicle Release Assays, Calcium imaging assay
    • CAS No.: 67995-63-5
    • MW: 3382 Da
  • Muscarinic Toxin 3
    Bioassay Tested
    Muscarinic Toxin 3
    A potent antagonist selective for the M4 muscarinic acetylcholine receptor (M4 mAChR) and a non-selective antagonist for several α1- and α2-adrenoceptor subtypes
    • Product Code: M-140
    • Short Description: A potent antagonist selective for the M4 muscarinic acetylcholine receptor (M4 mAChR) and a non-selective antagonist for several α1- and α2-adrenoceptor subtypes
    • Applications: Calcium imaging assay
    • MW: 7379 Da
  • α-Latrotoxin
    Bioassay Tested
    α-Latrotoxin
    A potent inducer of massive neurotransmitter release via presynaptic neurexin and latrophilin receptors
    • Product Code: LSP-130
    • Short Description: A potent inducer of massive neurotransmitter release via presynaptic neurexin and latrophilin receptors
    • Applications: Electrophysiology, Synaptic recording
    • CAS No.: 65988-34-3
    • MW: 130 kDa
  • GW-2580
    Bioassay Tested
    GW-2580
    An Inhibitor of Trk Receptors and cFMS/CSF-1 Receptor Kinases
    • Product Code: G-255
    • Short Description: An Inhibitor of Trk Receptors and cFMS/CSF-1 Receptor Kinases
    • CAS No.: 870483-87-7
    • MW: 366.41
  • GW441756
    Bioassay Tested
    GW441756
    A Potent Inhibitor of TrkA
    • Product Code: G-190
    • Short Description: A Potent Inhibitor of TrkA
    • CAS No.: 504433-23-2
    • MW: 275.3
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