Cardiac Arrhythmia

Cardiac Arrhythmia

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

245 Results
  • GS967
    Bioassay Tested
    GS967
    A potent and selective blocker of cardiac late sodium channel (late I(Na)).
    • Product Code: G-225
    • Short Description: A potent and selective blocker of cardiac late sodium channel (late I(Na)).
    • CAS No.: 1262618-39-2
    • MW: 347.2
  • GsAF-I
    Bioassay Tested
    GsAF-I
    A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Product Code: STG-300
    • Short Description: A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Applications: Electrophysiology
    • MW: 3707.5 Da
  • GsAF-II
    Bioassay Tested
    GsAF-II
    A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Product Code: STG-350
    • Short Description: A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Applications: Electrophysiology
    • MW: 3979.8 Da
  • Guangxitoxin-1E
    Bioassay Tested
    Guangxitoxin-1E
    A potent gating modifier of KV2.1 and KV2.2 K+ channels that also inhibits KV4.3 channels
    • Product Code: STG-200
    • Short Description: A potent gating modifier of KV2.1 and KV2.2 K+ channels that also inhibits KV4.3 channels
    • Applications: Electrophysiology
    • CAS No.: 1233152-82-3
    • MW: 3948.7 Da
  • Guinea pig Anti-Ca<sub>V</sub>1.2 (CACNA1C) Antibody
    Guinea pig Anti-CaV1.2 (CACNA1C) Antibody
    A Guinea Pig Polyclonal Antibody to CaV1.2 (CACNA1C) Channel
    • Product Code: ACC-003-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to CaV1.2 (CACNA1C) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Voltage-dependent L-type calcium channel subunit α1C
  • Guinea pig Anti-HCN1 Antibody
    Guinea pig Anti-HCN1 Antibody
    A Guinea Pig Polyclonal Antibody to HCN1 Channel
    • Product Code: APC-056-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to HCN1 Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Hyperpolarization-activated cyclic nucleotide-gated potassium channel 1, HAC2, Brain cyclic nucleotide-gated channel 1, BCNG1, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
  • Guinea pig Anti-HCN4 Antibody
    Guinea pig Anti-HCN4 Antibody
    A Guinea Pig Polyclonal Antibody to HCN4 Channel
    • Product Code: APC-052-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to HCN4 Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4
  • Guinea pig Anti-KCNN2 (K<sub>Ca</sub>2.2, SK2) Antibody
    Guinea pig Anti-KCNN2 (KCa2.2, SK2) Antibody
    A Guinea Pig Polyclonal Antibody to KCNN2 (KCa2.2, SK2) Channel
    • Product Code: APC-028-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to KCNN2 (KCa2.2, SK2) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot
    • Target: SKCa2, Small conductance calcium-activated potassium channel protein 2, Apamin-sensitive small conductance Ca2+-dependent K+ channel
  • Guinea pig Anti-KCNQ1 Antibody
    Guinea pig Anti-KCNQ1 Antibody
    A Guinea Pig Polyclonal Antibody to KCNQ1 (KV7.1) Channel
    • Product Code: APC-022-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to KCNQ1 (KV7.1) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: KV7.1, Voltage-gated potassium channel QKT subfamily member 1, KVLQT1
  • Guinea pig Anti-K<sub>ir</sub>2.1/KCNJ2 Antibody
    Guinea pig Anti-Kir2.1/KCNJ2 Antibody
    A Guinea Pig Polyclonal Antibody to Kir2.1 (KCNJ2) Channel
    • Product Code: APC-026-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Kir2.1 (KCNJ2) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot
    • Target: Inward rectifier potassium channel 2, IRK1, HIRK1, LQT7, SQT3
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