Cardiac Failure

Cardiac Failure

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

286 Results
  • Zacopride (hydrochloride)
    Bioassay Tested
    Zacopride (hydrochloride)
    A Potent Antagonist of 5-HT3 Receptors and an Agonist of 5-HT4 Receptors
    • Product Code: Z-110
    • Short Description: A Potent Antagonist of 5-HT3 Receptors and an Agonist of 5-HT4 Receptors
    • CAS No.: 101303-98-4
    • MW: 346.25
  • Zibotentan
    Bioassay Tested
    Zibotentan
    A Selective Antagonist of Endothelin A Receptors
    • Product Code: Z-130
    • Short Description: A Selective Antagonist of Endothelin A Receptors
    • CAS No.: 186497-07-4
    • MW: 424.43
  • µ-Conotoxin BuIIIC
    Bioassay Tested
    µ-Conotoxin BuIIIC
    A potent and selective blocker of skeletal muscle NaV1.4 voltage-gated sodium channels
    • Product Code: STC-690
    • Short Description: A potent and selective blocker of skeletal muscle NaV1.4 voltage-gated sodium channels
    • Applications: Electrophysiology
    • MW: 3006 Da
  • µ-Conotoxin CnIIIC
    Bioassay Tested
    µ-Conotoxin CnIIIC
    A potent blocker of skeletal muscle NaV1.4 and neuronal NaV1.2 sodium channels, which also inhibits the α3/β2 nAChR
    • Product Code: STC-640
    • Short Description: A potent blocker of skeletal muscle NaV1.4 and neuronal NaV1.2 sodium channels, which also inhibits the α3/β2 nAChR
    • Applications: Electrophysiology
    • MW: 2376 Da
  • µ-Conotoxin SxIIIA
    Bioassay Tested
    µ-Conotoxin SxIIIA
    A potent blocker of the skeletal muscle NaV1.4 channel, with moderate activity on neuronal NaV1.1, NaV1.2, and NaV1.6 channels
    • Product Code: STC-645
    • Short Description: A potent blocker of the skeletal muscle NaV1.4 channel, with moderate activity on neuronal NaV1.1, NaV1.2, and NaV1.6 channels
    • Applications: Electrophysiology
    • MW: 2271.7 Da
  • α-Asarone
    Bioassay Tested
    α-Asarone
    An Antagonist of NaV Channels, GABA(A) Receptors, NMDA Receptors and an Inhibitor of TrkB Receptor
    • Product Code: A-260
    • Short Description: An Antagonist of NaV Channels, GABA(A) Receptors, NMDA Receptors and an Inhibitor of TrkB Receptor
    • CAS No.: 2883-98-9
    • MW: 208.3
  • α-Conotoxin EI
    Bioassay Tested
    α-Conotoxin EI
    A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Product Code: STC-900
    • Short Description: A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Applications: Electrophysiology
    • CAS No.: 170663-33-9
    • MW: 2093.4 Da
  • α-Conotoxin EIIB
    Bioassay Tested
    α-Conotoxin EIIB
    A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-230
    • Short Description: A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1754.5 Da
  • α-Conotoxin GI
    Bioassay Tested
    α-Conotoxin GI
    A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Product Code: STC-500
    • Short Description: A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Applications: Electrophysiology
    • CAS No.: 76862-65-2
    • MW: 1437.6 Da
  • α-Conotoxin MI
    Bioassay Tested
    α-Conotoxin MI
    A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-370
    • Short Description: A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 83481-45-2
    • MW: 1493.7 Da
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