Hypertension

Hypertension

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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561 Results
  • GS967
    Bioassay Tested
    GS967
    A potent and selective blocker of cardiac late sodium channel (late I(Na)).
    • Product Code: G-225
    • Short Description: A potent and selective blocker of cardiac late sodium channel (late I(Na)).
    • CAS No.: 1262618-39-2
    • MW: 347.2
  • GsMTx-4
    Bioassay Tested
    GsMTx-4
    A potent inhibitor of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Product Code: STG-100
    • Short Description: A potent inhibitor of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Applications: Electrophysiology
    • CAS No.: 1209500-46-8
    • MW: 4096 Da
  • GTx1-15
    Bioassay Tested
    GTx1-15
    A blocker of voltage-gated Na+ and T-Type Ca2+ channels
    • Product Code: STT-300
    • Short Description: A blocker of voltage-gated Na+ and T-Type Ca2+ channels
    • Applications: Electrophysiology
    • MW: 4073.8 Da
  • Guangxitoxin-1E
    Bioassay Tested
    Guangxitoxin-1E
    A potent gating modifier of KV2.1 and KV2.2 K+ channels that also inhibits KV4.3 channels
    • Product Code: STG-200
    • Short Description: A potent gating modifier of KV2.1 and KV2.2 K+ channels that also inhibits KV4.3 channels
    • Applications: Electrophysiology
    • CAS No.: 1233152-82-3
    • MW: 3948.7 Da
  • Guinea Pig Anti-Alpha 1 Na<sup>+</sup>/K<sup>+</sup> ATPase Antibody
    Guinea Pig Anti-Alpha 1 Na+/K+ ATPase Antibody
    A Guinea Pig Polyclonal Antibody to Alpha 1 Na+/K+ ATPase
    • Product Code: ANP-001-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Alpha 1 Na+/K+ ATPase
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: ATP1A1, Sodium/potassium ATPase catalytic subunit alpha-1, Sodium pump subunit alpha-1
  • Guinea pig Anti-Ca<sub>V</sub>1.3 (CACNA1D) Antibody
    Guinea pig Anti-CaV1.3 (CACNA1D) Antibody
    A Guinea Pig Polyclonal Antibody to CaV1.3 (CACNA1D) Channel
    • Product Code: ACC-005-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to CaV1.3 (CACNA1D) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Voltage-dependent L-type calcium channel subunit α1D
  • Guinea pig Anti-Endothelin Receptor B Antibody
    Guinea pig Anti-Endothelin Receptor B Antibody
    A Guinea Pig Polyclonal Antibody to Endothelin Receptor B
    • Product Code: AER-002-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Endothelin Receptor B
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot
    • Target: EDNRB, ET-B, ETB, ETRB, Endothelin B receptor, Endothelin receptor non-selective type
  • Guinea pig Anti-HCN4 Antibody
    Guinea pig Anti-HCN4 Antibody
    A Guinea Pig Polyclonal Antibody to HCN4 Channel
    • Product Code: APC-052-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to HCN4 Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4
  • Guinea pig Anti-KCNMA1 (K<sub>Ca</sub>1.1) (1097-1196) Antibody
    Guinea pig Anti-KCNMA1 (KCa1.1) (1097-1196) Antibody
    A Guinea Pig Polyclonal Antibody to KCNMA1 (KCa1.1) Channel
    • Product Code: APC-021-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to KCNMA1 (KCa1.1) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot
    • Target: Large conductance calcium-activated potassium channel subfamily M subunit alpha-1, BKCa alpha, Maxi K+, Slo1
  • Guinea pig Anti-KCNQ1 Antibody
    Guinea pig Anti-KCNQ1 Antibody
    A Guinea Pig Polyclonal Antibody to KCNQ1 (KV7.1) Channel
    • Product Code: APC-022-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to KCNQ1 (KV7.1) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: KV7.1, Voltage-gated potassium channel QKT subfamily member 1, KVLQT1
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