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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

2041 Results
  • L-Serine
    Bioassay Tested
    L-Serine
    An Agonist of Glycine Receptors
    • Product Code: S-135
    • Short Description: An Agonist of Glycine Receptors
    • CAS No.: 56-45-1
    • MW: 105.1
  • SKA-31
    Bioassay Tested
    SKA-31
    A Potent Activator of KCa3.1 and KCa2 Channels and a Blocker of TRPM7 Channel
    • Product Code: S-120
    • Short Description: A Potent Activator of KCa3.1 and KCa2 Channels and a Blocker of TRPM7 Channel
    • CAS No.: 40172-65-4
    • MW: 200.2
  • SNX-482
    Bioassay Tested
    SNX-482
    A potent blocker of CaV2.3 (R-type) calcium channels and the KV4.2, KV4.3 potassium channels
    • Product Code: RTS-500
    • Short Description: A potent blocker of CaV2.3 (R-type) calcium channels and the KV4.2, KV4.3 potassium channels
    • Applications: Electrophysiology
    • CAS No.: 203460-30-4
    • MW: 4495 Da
  • Lq2
    Bioassay Tested
    Lq2
    A potent blocker of Kir1.1 (ROMK1) channels, with lower affinity on KCa1.1 (BK) channels
    • Product Code: RTL-550
    • Short Description: A potent blocker of Kir1.1 (ROMK1) channels, with lower affinity on KCa1.1 (BK) channels
    • Applications: Electrophysiology
    • MW: 4353 Da
  • Chlorotoxin
    Bioassay Tested
    Chlorotoxin
    A potent scorpion toxin that preferentially binds to tumor cells by targeting multiple receptors including chloride channels,MMP-2, and Neuropilin-1
    • Product Code: RTC-450
    • Short Description: A potent scorpion toxin that preferentially binds to tumor cells by targeting multiple receptors including chloride channels,MMP-2, and Neuropilin-1
    • Applications: Cell-Based Assays, Electrophysiology, Calcium imaging assay
    • CAS No.: 163515-35-3
    • MW: 3996.7 Da
  • Aa1 Toxin
    Bioassay Tested
    Aa1 Toxin
    A potent and selective blocker of KV4 (A-type) voltage-gated potassium channels
    • Product Code: RTA-400
    • Short Description: A potent and selective blocker of KV4 (A-type) voltage-gated potassium channels
    • Applications: Electrophysiology
    • MW: 3868 Da
  • Resiniferatoxin
    Bioassay Tested
    Resiniferatoxin
    A Potent and Selective Activator of TRPV1 Channel
    • Product Code: R-400
    • Short Description: A Potent and Selective Activator of TRPV1 Channel
    • CAS No.: 57444-62-9
    • MW: 628.72
  • R214127
    Bioassay Tested
    R214127
    A Potent, Selective, and Non-Competitive Antagonist of mGluR1
    • Product Code: R-215
    • Short Description: A Potent, Selective, and Non-Competitive Antagonist of mGluR1
    • CAS No.: 409345-76-2
    • MW: 303.36
  • Ro-51
    Bioassay Tested
    Ro-51
    A Highly Potent and Selective Antagonist of P2X3 and P2X2/3 Receptors
    • Product Code: R-195
    • Short Description: A Highly Potent and Selective Antagonist of P2X3 and P2X2/3 Receptors
    • CAS No.: 1050670-85-3
    • MW: 474.29
  • RO-3
    Bioassay Tested
    RO-3
    A Potent and Selective Antagonist of P2X3 and P2X2/3 Receptors
    • Product Code: R-190
    • Short Description: A Potent and Selective Antagonist of P2X3 and P2X2/3 Receptors
    • CAS No.: 1026582-88-6
    • MW: 302.37
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