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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

2045 Results
  • Charybdotoxin
    Bioassay Tested
    Charybdotoxin
    A potent broad-spectrum blocker of K+ channels, including KV1.2, KV1.3, KV1.6, KCa1.1 and KCa3.1 channels
    • Product Code: STC-325
    • Short Description: A potent broad-spectrum blocker of K+ channels, including KV1.2, KV1.3, KV1.6, KCa1.1 and KCa3.1 channels
    • Applications: Electrophysiology
    • CAS No.: 95751-30-7
    • MW: 4296 Da
  • α-Conotoxin MrIC
    Bioassay Tested
    α-Conotoxin MrIC
    An α7 nAChR potent antagonist that functions as a PAM-dependent biased agonist
    • Product Code: STC-320
    • Short Description: An α7 nAChR potent antagonist that functions as a PAM-dependent biased agonist
    • Applications: Electrophysiology
    • MW: 1835 Da
  • α-Conotoxin AuIB
    Bioassay Tested
    α-Conotoxin AuIB
    An antagonist of mammalian α3/β4 neuronal nAChR that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-310
    • Short Description: An antagonist of mammalian α3/β4 neuronal nAChR that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • CAS No.: 216299-21-7
    • MW: 1572.8 Da
  • µ-Conotoxin GIIIA
    Bioassay Tested
    µ-Conotoxin GIIIA
    A potent and selective blocker of skeletal muscle NaV1.4 voltage-gated sodium channels
    • Product Code: STC-280
    • Short Description: A potent and selective blocker of skeletal muscle NaV1.4 voltage-gated sodium channels
    • Applications: Electrophysiology
    • CAS No.: 129129-65-3
    • MW: 2609 Da
  • Cd1a Toxin
    Bioassay Tested
    Cd1a Toxin
    A potent blocker of NaV1.7 voltage-gated sodium channels and modest blocker of N-type (CaV2.2) calcium channels
    • Product Code: STC-260
    • Short Description: A potent blocker of NaV1.7 voltage-gated sodium channels and modest blocker of N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 4030.6 Da
  • α-Conotoxin EIIB
    Bioassay Tested
    α-Conotoxin EIIB
    A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-230
    • Short Description: A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1754.5 Da
  • α-Conotoxin GeXIVA
    Bioassay Tested
    α-Conotoxin GeXIVA
    A potent antagonist of α9α10 nAChRs with negligible activity on other nAChR subtypes
    • Product Code: STC-220
    • Short Description: A potent antagonist of α9α10 nAChRs with negligible activity on other nAChR subtypes
    • Applications: Electrophysiology
    • CAS No.: 2010167-25-4
    • MW: 3453 Da
  • ω-Conotoxin Bu8
    Bioassay Tested
    ω-Conotoxin Bu8
    A potent and specific blocker of N-type (CaV2.2) calcium channels
    • Product Code: STC-180
    • Short Description: A potent and specific blocker of N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 2753 Da
  • Cono AIVGRPRF-amide
    Bioassay Tested
    Cono AIVGRPRF-amide
    A specific potentiator of ASIC3 channels
    • Product Code: STC-174
    • Short Description: A specific potentiator of ASIC3 channels
    • Applications: Electrophysiology
    • MW: 914 Da
  • Cono VGRPRF-amide
    Bioassay Tested
    Cono VGRPRF-amide
    A specific potentiator of ASIC3 channels
    • Product Code: STC-172
    • Short Description: A specific potentiator of ASIC3 channels
    • Applications: Electrophysiology
    • MW: 730 Da
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