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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

2041 Results
  • Ceratotoxin-2
    Bioassay Tested
    Ceratotoxin-2
    A potent blocker of central nervous system voltage-gated Na+ channels
    • Product Code: STC-100
    • Short Description: A potent blocker of central nervous system voltage-gated Na+ channels
    • Applications: Electrophysiology
    • MW: 4092.7 Da
  • α-Conotoxin GIC
    Bioassay Tested
    α-Conotoxin GIC
    A potent and selective antagonist of α3β2 and α6-containing nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-070
    • Short Description: A potent and selective antagonist of α3β2 and α6-containing nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1609.8 Da
  • Cn2 Toxin
    Bioassay Tested
    Cn2 Toxin
    A potent and selective activator of NaV1.6 channels
    • Product Code: STC-060
    • Short Description: A potent and selective activator of NaV1.6 channels
    • Applications: Electrophysiology
    • MW: 7588.6 Da
  • α-Conotoxin MII
    Bioassay Tested
    α-Conotoxin MII
    A potent and selective antagonist of neuronal α3β2 and α6β2*-containing nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-040
    • Short Description: A potent and selective antagonist of neuronal α3β2 and α6β2*-containing nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 175735-93-0
    • MW: 1711 Da
  • α-Conotoxin BuIA
    Bioassay Tested
    α-Conotoxin BuIA
    A broad-spectrum nAChR antagonist used to kinetically distinguish between β2- and β4-containing receptors
    • Product Code: STC-030
    • Short Description: A broad-spectrum nAChR antagonist used to kinetically distinguish between β2- and β4-containing receptors
    • Applications: Electrophysiology
    • MW: 1311.6 Da
  • α-Conotoxin Bt1.8
    Bioassay Tested
    α-Conotoxin Bt1.8
    A potent and selective antagonist of neuronal α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-020
    • Short Description: A potent and selective antagonist of neuronal α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1646 Da
  • α-Conotoxin RgIA
    Bioassay Tested
    α-Conotoxin RgIA
    A potent antagonist of α9α10 nAChRs that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-010
    • Short Description: A potent antagonist of α9α10 nAChRs that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • MW: 1571 Da
  • BeKm-1
    Bioassay Tested
    BeKm-1
    A potent and selective blocker of hERG (KV11.1) potassium channels
    • Product Code: STB-470
    • Short Description: A potent and selective blocker of hERG (KV11.1) potassium channels
    • Applications: Electrophysiology
    • CAS No.: 524962-01-4
    • MW: 4092 Da
  • BDS-I
    Bioassay Tested
    BDS-I
    A blocker of KV potassium channels and a modulator that slows the inactivation of NaV sodium channels (particularly NaV1.7)
    • Product Code: STB-400
    • Short Description: A blocker of KV potassium channels and a modulator that slows the inactivation of NaV sodium channels (particularly NaV1.7)
    • Applications: Electrophysiology
    • CAS No.: 207621-38-3
    • MW: 4708 Da
  • BmKI Toxin
    Bioassay Tested
    BmKI Toxin
    A potent activator/modulator that delays the fast inactivation of NaV1.5, NaV1.6, and NaV1.3 voltage-gated sodium channels
    • Product Code: STB-100
    • Short Description: A potent activator/modulator that delays the fast inactivation of NaV1.5, NaV1.6, and NaV1.3 voltage-gated sodium channels
    • Applications: Electrophysiology
    • MW: 7217 Da
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