Neuroimmunology

Neuroimmunology

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

224 Results
  • µ/ω-TRTX-Tap1a
    Bioassay Tested
    µ/ω-TRTX-Tap1a
    A potent blocker/gating-modifier of multiple NaV and T-type (CaV3.1, CaV3.2) channels
    • Product Code: STT-600
    • Applications: Electrophysiology
    • MW: 4182.7 Da
  • α-Asarone
    Bioassay Tested
    α-Asarone
    An Antagonist of NaV Channels, GABA(A) Receptors, NMDA Receptors and an Inhibitor of TrkB Receptor
    • Product Code: A-260
    • CAS No.: 2883-98-9
    • MW: 208.3
  • α-Conotoxin EI
    Bioassay Tested
    α-Conotoxin EI
    A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Product Code: STC-900
    • Short Description: A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Applications: Electrophysiology
    • CAS No.: 170663-33-9
    • MW: 2093.4 Da
  • α-Conotoxin EIIB
    Bioassay Tested
    α-Conotoxin EIIB
    A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-230
    • Short Description: A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1754.5 Da
  • α-Conotoxin GI
    Bioassay Tested
    α-Conotoxin GI
    A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Product Code: STC-500
    • Short Description: A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Applications: Electrophysiology
    • CAS No.: 76862-65-2
    • MW: 1437.6 Da
  • α-Conotoxin MI
    Bioassay Tested
    α-Conotoxin MI
    A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-370
    • Short Description: A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 83481-45-2
    • MW: 1493.7 Da
  • α-Conotoxin PeIA
    Bioassay Tested
    α-Conotoxin PeIA
    An antagonist of neuronal nAChRs (α9α10, α6-containing, and α3/β2) that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-970
    • Applications: Electrophysiology
    • CAS No.: 866876-88-2
    • MW: 1652 Da
  • α-Conotoxin SI
    Bioassay Tested
    α-Conotoxin SI
    A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-825
    • Short Description: A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 115797-06-3
    • MW: 1353.6 Da
  • α-Latrotoxin
    Bioassay Tested
    α-Latrotoxin
    A potent inducer of massive neurotransmitter release via presynaptic neurexin and latrophilin receptors
    • Product Code: LSP-130
    • Short Description: A potent inducer of massive neurotransmitter release via presynaptic neurexin and latrophilin receptors
    • Applications: Electrophysiology, Synaptic recording
    • CAS No.: 65988-34-3
    • MW: 130 kDa
  • α-Pompilidotoxin
    Bioassay Tested
    α-Pompilidotoxin
    An enhancer (modulator) of NaV currents
    • Product Code: P-170
    • Short Description: An enhancer (modulator) of NaV currents
    • Applications: Electrophysiology
    • MW: 1530 Da
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