Neurodegenerative Diseases

Neurodegenerative Diseases

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

941 Results
  • mouse NGF 2.5S-Biotin
    Bioassay Tested
    mouse NGF 2.5S-Biotin
    A biotinylated mouse NGF 2.5S for imaging and sensitive detection of TrkA and p75NTR receptors
    • Product Code: N-240-B
    • Short Description: A biotinylated mouse NGF 2.5S for imaging and sensitive detection of TrkA and p75NTR receptors
    • Label: Biotin
    • Applications: Cell Culture, Survival assay, Fluorescence staining, Live cell imaging, Immunofluorescence, Neurite outgrowth assay
    • MW: ~26 kDa
  • Mouse NGF/proNGF Neutralizing Antibody
    Mouse NGF/proNGF Neutralizing Antibody
    A Mouse Monoclonal Antibody to NGF and proNGF Designed to Neutralize their Biological Functions
    • Product Code: ALM-006
    • Short Description: A Mouse Monoclonal Antibody to NGF and proNGF Designed to Neutralize their Biological Functions
    • Host: Mouse
    • Label: Unconjugated
    • Reactivity: Human, Mouse
    • Applications: Indirect ELISA, Neutralization
    • Target: Nerve growth factor
  • MPX-004
    Bioassay Tested
    MPX-004
    A Potent and Selective Antagonist of GluN2A-containing NMDA Receptors
    • Product Code: M-280
    • Short Description: A Potent and Selective Antagonist of GluN2A-containing NMDA Receptors
    • CAS No.: 77086-22-7
    • MW: 455.91
  • Muscarinic Toxin 3
    Bioassay Tested
    Muscarinic Toxin 3
    A potent antagonist selective for the M4 muscarinic acetylcholine receptor (M4 mAChR) and a non-selective antagonist for several α1- and α2-adrenoceptor subtypes
    • Product Code: M-140
    • Short Description: A potent antagonist selective for the M4 muscarinic acetylcholine receptor (M4 mAChR) and a non-selective antagonist for several α1- and α2-adrenoceptor subtypes
    • Applications: Calcium imaging assay
    • MW: 7379 Da
  • Native mouse NGF 2.5S protein (99%)
    Bioassay Tested
    Native mouse NGF 2.5S protein (99%)
    A native mouse neurotrophin purified from submaxillary glands that promotes neuronal survival and neurite outgrowth via TrkA and p75NTR receptors
    • Product Code: N-240
    • Short Description: A native mouse neurotrophin purified from submaxillary glands that promotes neuronal survival and neurite outgrowth via TrkA and p75NTR receptors
    • Applications: Cell Culture, Survival assay, Neurite outgrowth assay
    • CAS No.: 93928-24-6
    • MW: 26 kDa
  • Native mouse NGF 2.5S protein (>95%)
    Bioassay Tested
    Native mouse NGF 2.5S protein (>95%)
    A native mouse neurotrophin purified from submaxillary glands that promotes neuronal survival and neurite outgrowth via TrkA and p75NTR receptors
    • Product Code: N-100
    • Short Description: A native mouse neurotrophin purified from submaxillary glands that promotes neuronal survival and neurite outgrowth via TrkA and p75NTR receptors
    • Applications: Cell Culture, ELISA control, Survival assay, Neurite outgrowth assay
    • CAS No.: 93928-24-6
    • MW: 26 kDa
  • Native mouse NGF 7S protein
    Bioassay Tested
    Native mouse NGF 7S protein
    A native mouse nerve growth factor (NGF) 7S protein complex that promotes neuronal survival and neurite outgrowth via TrkA and p75NTR receptors
    • Product Code: N-130
    • Short Description: A native mouse nerve growth factor (NGF) 7S protein complex that promotes neuronal survival and neurite outgrowth via TrkA and p75NTR receptors
    • Applications: Cell Culture, Survival assay, Neurite outgrowth assay
    • CAS No.: 93928-24-6
    • MW: 130 kDa
  • Na<sub>V</sub>1.1-Compound 3a
    Bioassay Tested
    NaV1.1-Compound 3a
    A Modulator of NaV1.1 Channel
    • Product Code: CMN-002
    • Short Description: A Modulator of NaV1.1 Channel
    • MW: 344.41
  • NCS1 Blocking Peptide
    NCS1 Blocking Peptide
    A Blocking Peptide for Anti-NCS1 Antibody
    • Product Code: BLP-CS001
    • Short Description: A Blocking Peptide for Anti-NCS1 Antibody
    • Applications: Western blot, Immunohistochemistry
    • Target: NCS1
  • Nectin-1/PVRL1 (extracellular) Blocking Peptide
    Nectin-1/PVRL1 (extracellular) Blocking Peptide
    A Blocking Peptide for Anti-Nectin-1/PVRL1 (extracellular) Antibody
    • Product Code: BLP-NR051
    • Short Description: A Blocking Peptide for Anti-Nectin-1/PVRL1 (extracellular) Antibody
    • Applications: Western blot, Immunohistochemistry
    • Target: NECTIN1
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