Neurodegenerative Diseases

Neurodegenerative Diseases

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

941 Results
  • α-Conotoxin AuIB
    Bioassay Tested
    α-Conotoxin AuIB
    An antagonist of mammalian α3/β4 neuronal nAChR that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-310
    • Short Description: An antagonist of mammalian α3/β4 neuronal nAChR that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • CAS No.: 216299-21-7
    • MW: 1572.8 Da
  • α-Conotoxin Bt1.8
    Bioassay Tested
    α-Conotoxin Bt1.8
    A potent and selective antagonist of neuronal α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-020
    • Short Description: A potent and selective antagonist of neuronal α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1646 Da
  • α-Conotoxin BuIA
    Bioassay Tested
    α-Conotoxin BuIA
    A broad-spectrum nAChR antagonist used to kinetically distinguish between β2- and β4-containing receptors
    • Product Code: STC-030
    • Short Description: A broad-spectrum nAChR antagonist used to kinetically distinguish between β2- and β4-containing receptors
    • Applications: Electrophysiology
    • MW: 1311.6 Da
  • α-Conotoxin GeXIVA
    Bioassay Tested
    α-Conotoxin GeXIVA
    A potent antagonist of α9α10 nAChRs with negligible activity on other nAChR subtypes
    • Product Code: STC-220
    • Short Description: A potent antagonist of α9α10 nAChRs with negligible activity on other nAChR subtypes
    • Applications: Electrophysiology
    • CAS No.: 2010167-25-4
    • MW: 3453 Da
  • α-Conotoxin GIC
    Bioassay Tested
    α-Conotoxin GIC
    A potent and selective antagonist of α3β2 and α6-containing nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-070
    • Short Description: A potent and selective antagonist of α3β2 and α6-containing nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1609.8 Da
  • α-Conotoxin ImI
    Bioassay Tested
    α-Conotoxin ImI
    A potent antagonist of the neuronal α3β2 and α7 nicotinic acetylcholine receptors (nAChR)
    • Product Code: C-290
    • Short Description: A potent antagonist of the neuronal α3β2 and α7 nicotinic acetylcholine receptors (nAChR)
    • Applications: Electrophysiology
    • CAS No.: 156467-85-5
    • MW: 1351 Da
  • α-Conotoxin ImI-ATTO Fluor-590
    Bioassay Tested
    α-Conotoxin ImI-ATTO Fluor-590
    A fluorescent probe for imaging and sensitive detection of α3β2 and α7 nicotinic acetylcholine receptors (nAChR)
    • Product Code: C-290-AR
    • Short Description: A fluorescent probe for imaging and sensitive detection of α3β2 and α7 nicotinic acetylcholine receptors (nAChR)
    • Label: ATTO 590
    • Applications: Electrophysiology, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: 1924 Da
  • α-Conotoxin MII
    Bioassay Tested
    α-Conotoxin MII
    A potent and selective antagonist of neuronal α3β2 and α6β2*-containing nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-040
    • Short Description: A potent and selective antagonist of neuronal α3β2 and α6β2*-containing nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 175735-93-0
    • MW: 1711 Da
  • α-Conotoxin MrIC
    Bioassay Tested
    α-Conotoxin MrIC
    An α7 nAChR potent antagonist that functions as a PAM-dependent biased agonist
    • Product Code: STC-320
    • Short Description: An α7 nAChR potent antagonist that functions as a PAM-dependent biased agonist
    • Applications: Electrophysiology
    • MW: 1835 Da
  • α-Conotoxin PeIA
    Bioassay Tested
    α-Conotoxin PeIA
    An antagonist of neuronal nAChRs (α9α10, α6-containing, and α3/β2) that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-970
    • Short Description: An antagonist of neuronal nAChRs (α9α10, α6-containing, and α3/β2) that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • CAS No.: 866876-88-2
    • MW: 1652 Da
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