Neurodegenerative Diseases

Neurodegenerative Diseases

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

941 Results
  • α-Conotoxin PIA
    Bioassay Tested
    α-Conotoxin PIA
    A potent and selective antagonist of neuronal α6*-containing nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-870
    • Short Description: A potent and selective antagonist of neuronal α6*-containing nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 669050-68-4
    • MW: 1981 Da
  • α-Conotoxin RgIA
    Bioassay Tested
    α-Conotoxin RgIA
    A potent antagonist of α9α10 nAChRs that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-010
    • Short Description: A potent antagonist of α9α10 nAChRs that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • MW: 1571 Da
  • α-Conotoxin TxID
    Bioassay Tested
    α-Conotoxin TxID
    A potent antagonist of α3β4 nAChRs that also inhibits α6/α3β4 nicotinic acetylcholine receptors
    • Product Code: STC-110
    • Short Description: A potent antagonist of α3β4 nAChRs that also inhibits α6/α3β4 nicotinic acetylcholine receptors
    • Applications: Electrophysiology
    • CAS No.: 1496617-64-1
    • MW: 1489.8 Da
  • α-Conotoxin Vc1.1
    Bioassay Tested
    α-Conotoxin Vc1.1
    A potent antagonist of α9α10 nAChRs and agonist of GABA(B) receptors
    • Product Code: STV-500
    • Short Description: A potent antagonist of α9α10 nAChRs and agonist of GABA(B) receptors
    • Applications: Electrophysiology
    • CAS No.: 740980-24-9
    • MW: 1807 Da
  • α-Dendrotoxin
    Bioassay Tested
    α-Dendrotoxin
    A potent and selective blocker of neuronal KV1.1, KV1.2, KV1.6 potassium channels
    • Product Code: D-350
    • Short Description: A potent and selective blocker of neuronal KV1.1, KV1.2, KV1.6 potassium channels
    • Applications: Electrophysiology
    • CAS No.: 74504-53-3
    • MW: 7047 Da
  • α-Dendrotoxin-ATTO Fluor-647N
    Bioassay Tested
    α-Dendrotoxin-ATTO Fluor-647N
    A fluorescent probe for imaging and sensitive detection of Kv1.1, Kv1.2, and Kv1.6 channels.
    • Product Code: D-350-FRN
    • Short Description: A fluorescent probe for imaging and sensitive detection of Kv1.1, Kv1.2, and Kv1.6 channels.
    • Label: ATTO 647N
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: ~7990 Da
  • α-Latrotoxin
    Bioassay Tested
    α-Latrotoxin
    A potent inducer of massive neurotransmitter release via presynaptic neurexin and latrophilin receptors
    • Product Code: LSP-130
    • Short Description: A potent inducer of massive neurotransmitter release via presynaptic neurexin and latrophilin receptors
    • Applications: Electrophysiology, Synaptic recording
    • CAS No.: 65988-34-3
    • MW: 130 kDa
  • β-Dendrotoxin
    Bioassay Tested
    β-Dendrotoxin
    A potent and selective blocker of neuronal KV1.1, KV1.2 potassium channels
    • Product Code: D-360
    • Short Description: A potent and selective blocker of neuronal KV1.1, KV1.2 potassium channels
    • Applications: Electrophysiology
    • MW: ~7000 Da
  • γ-Aminobutyric acid
    Bioassay Tested
    γ-Aminobutyric acid
    A Ligand of GABA(A), GABA(B) Receptors and GABA Transporters
    • Product Code: G-110
    • Short Description: A Ligand of GABA(A), GABA(B) Receptors and GABA Transporters
    • CAS No.: 56-12-2
    • MW: 103.1
  • κ-Bungarotoxin
    Bioassay Tested
    κ-Bungarotoxin
    A potent antagonist of α3-containing neuronal nicotinic acetylcholine receptors (nAChRs)
    • Product Code: B-300
    • Short Description: A potent antagonist of α3-containing neuronal nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 7265 Da
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