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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

771 Results
  • Calcicludine
    Bioassay Tested
    Calcicludine
    A non-selective blocker of multiple high-voltage-activated calcium channels, including L-type (CaV1.2, 1.3), P-type (CaV2.1), and N-type (CaV2.2) channels
    • Product Code: SPC-650
    • Short Description: A non-selective blocker of multiple high-voltage-activated calcium channels, including L-type (CaV1.2, 1.3), P-type (CaV2.1), and N-type (CaV2.2) channels
    • Applications: Electrophysiology
    • CAS No.: 178037-96-2
    • MW: 6980 Da
  • Cannabichromene
    Bioassay Tested
    Cannabichromene
    An Activator of TRPA1 Channels and an Antagonist of Cannabinoid Receptor 1 and TRPM8 Channels
    • Product Code: C-315
    • Short Description: An Activator of TRPA1 Channels and an Antagonist of Cannabinoid Receptor 1 and TRPM8 Channels
    • CAS No.: 20675-51-8
    • MW: 314.5
  • Capsaicin
    Bioassay Tested
    Capsaicin
    A Powerful TRPV1 Agonist
    • Product Code: C-125
    • Short Description: A Powerful TRPV1 Agonist
    • CAS No.: 404-86-4
    • MW: 305.4
  • Capsazepine
    Bioassay Tested
    Capsazepine
    A Selective TRPV1 Blocker and an Activator of ENaCγ Channels
    • Product Code: C-120
    • Short Description: A Selective TRPV1 Blocker and an Activator of ENaCγ Channels
    • CAS No.: 138977-28-3
    • MW: 376.9
  • Capsiate
    Bioassay Tested
    Capsiate
    A TRPA1 and TRPV1 Channel Activator
    • Product Code: C-255
    • Short Description: A TRPA1 and TRPV1 Channel Activator
    • CAS No.: 205687-01-0
    • MW: 306.4
  • Cd1a Toxin
    Bioassay Tested
    Cd1a Toxin
    A potent blocker of NaV1.7 voltage-gated sodium channels and modest blocker of N-type (CaV2.2) calcium channels
    • Product Code: STC-260
    • Short Description: A potent blocker of NaV1.7 voltage-gated sodium channels and modest blocker of N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 4030.6 Da
  • Ceratotoxin-1
    Bioassay Tested
    Ceratotoxin-1
    A potent blocker of neuronal NaV1.2 voltage-gated sodium channels that also inhibits NaV1.1, NaV1.4, NaV1.5 and NaV1.7 channels
    • Product Code: STC-680
    • Short Description: A potent blocker of neuronal NaV1.2 voltage-gated sodium channels that also inhibits NaV1.1, NaV1.4, NaV1.5 and NaV1.7 channels
    • Applications: Electrophysiology
    • MW: 4044.6 Da
  • Ceratotoxin-2
    Bioassay Tested
    Ceratotoxin-2
    A potent blocker of central nervous system voltage-gated Na+ channels
    • Product Code: STC-100
    • Short Description: A potent blocker of central nervous system voltage-gated Na+ channels
    • Applications: Electrophysiology
    • MW: 4092.7 Da
  • CFMTI
    Bioassay Tested
    CFMTI
    A Potent and Selective Antagonist of mGluR1 Receptors
    • Product Code: C-365
    • Short Description: A Potent and Selective Antagonist of mGluR1 Receptors
    • CAS No.: 864864-17-5
    • MW: 349.4
  • CGP-37849
    Bioassay Tested
    CGP-37849
    A Potent and Selective Antagonist of NMDA Receptors
    • Product Code: C-325
    • Short Description: A Potent and Selective Antagonist of NMDA Receptors
    • CAS No.: 127910-31-0
    • MW: 209.14
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