Synaptic Function

Synaptic Function

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

226 Results
  • α-Conotoxin PeIA
    Bioassay Tested
    α-Conotoxin PeIA
    An antagonist of neuronal nAChRs (α9α10, α6-containing, and α3/β2) that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-970
    • Short Description: An antagonist of neuronal nAChRs (α9α10, α6-containing, and α3/β2) that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • CAS No.: 866876-88-2
    • MW: 1652 Da
  • α-Dendrotoxin
    Bioassay Tested
    α-Dendrotoxin
    A potent and selective blocker of neuronal KV1.1, KV1.2, KV1.6 potassium channels
    • Product Code: D-350
    • Short Description: A potent and selective blocker of neuronal KV1.1, KV1.2, KV1.6 potassium channels
    • Applications: Electrophysiology
    • CAS No.: 74504-53-3
    • MW: 7047 Da
  • α-Dendrotoxin-ATTO Fluor-647N
    Bioassay Tested
    α-Dendrotoxin-ATTO Fluor-647N
    A fluorescent probe for imaging and sensitive detection of Kv1.1, Kv1.2, and Kv1.6 channels.
    • Product Code: D-350-FRN
    • Short Description: A fluorescent probe for imaging and sensitive detection of Kv1.1, Kv1.2, and Kv1.6 channels.
    • Label: ATTO 647N
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: ~7990 Da
  • β-Dendrotoxin
    Bioassay Tested
    β-Dendrotoxin
    A potent and selective blocker of neuronal KV1.1, KV1.2 potassium channels
    • Product Code: D-360
    • Short Description: A potent and selective blocker of neuronal KV1.1, KV1.2 potassium channels
    • Applications: Electrophysiology
    • MW: ~7000 Da
  • γ-Aminobutyric acid
    Bioassay Tested
    γ-Aminobutyric acid
    A Ligand of GABA(A), GABA(B) Receptors and GABA Transporters
    • Product Code: G-110
    • Short Description: A Ligand of GABA(A), GABA(B) Receptors and GABA Transporters
    • CAS No.: 56-12-2
    • MW: 103.1
  • δ-Dendrotoxin
    Bioassay Tested
    δ-Dendrotoxin
    A potent and specific blocker of KV1.1 channels, with lower potency for KV1.6 and Kir1.1 (ROMK1) channels
    • Product Code: D-380
    • Short Description: A potent and specific blocker of KV1.1 channels, with lower potency for KV1.6 and Kir1.1 (ROMK1) channels
    • Applications: Electrophysiology
    • MW: 6568 Da
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