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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

Category: Hypertension
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561 Results
  • µ-Conotoxin SxIIIA
    Bioassay Tested
    µ-Conotoxin SxIIIA
    A potent blocker of the skeletal muscle NaV1.4 channel, with moderate activity on neuronal NaV1.1, NaV1.2, and NaV1.6 channels
    • Product Code: STC-645
    • Applications: Electrophysiology
    • MW: 2271.7 Da
  • µ-Conotoxin CnIIIC
    Bioassay Tested
    µ-Conotoxin CnIIIC
    A potent blocker of skeletal muscle NaV1.4 and neuronal NaV1.2 sodium channels, which also inhibits the α3/β2 nAChR
    • Product Code: STC-640
    • Applications: Electrophysiology
    • MW: 2376 Da
  • αC-Conotoxin PrXA
    Bioassay Tested
    αC-Conotoxin PrXA
    A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Product Code: STC-620
    • Short Description: A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Applications: Electrophysiology
    • MW: 3541 Da
  • αA-Conotoxin PIVA
    Bioassay Tested
    αA-Conotoxin PIVA
    A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Product Code: STC-600
    • Short Description: A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Applications: Electrophysiology
    • MW: 2649 Da
  • αA-Conotoxin OIVA
    Bioassay Tested
    αA-Conotoxin OIVA
    A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-520
    • Short Description: A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 123456
    • MW: 1848 Da
  • α-Conotoxin GI
    Bioassay Tested
    α-Conotoxin GI
    A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Product Code: STC-500
    • Short Description: A potent and selective antagonist of the muscle-type nicotinic acetylcholine receptor (nAChR)
    • Applications: Electrophysiology
    • CAS No.: 76862-65-2
    • MW: 1437.6 Da
  • Chlorotoxin
    Chlorotoxin
    A potent scorpion toxin that preferentially binds to tumor cells by targeting multiple receptors including chloride channels,MMP-2, and Neuropilin-1
    • Product Code: STC-460
    • Applications: Cell-Based Assays, Electrophysiology, Calcium imaging assay
    • CAS No.: 163515-35-3
    • MW: 3995.8 Da
  • α-Conotoxin MI
    Bioassay Tested
    α-Conotoxin MI
    A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-370
    • Short Description: A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • CAS No.: 83481-45-2
    • MW: 1493.7 Da
  • Charybdotoxin
    Bioassay Tested
    Charybdotoxin
    A potent broad-spectrum blocker of K+ channels, including KV1.2, KV1.3, KV1.6, KCa1.1 and KCa3.1 channels
    • Product Code: STC-325
    • Applications: Electrophysiology
    • CAS No.: 95751-30-7
    • MW: 4296 Da
  • α-Conotoxin EIIB
    Bioassay Tested
    α-Conotoxin EIIB
    A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Product Code: STC-230
    • Short Description: A potent antagonist of muscle α1/β1/γ/δ nicotinic acetylcholine receptors (nAChRs)
    • Applications: Electrophysiology
    • MW: 1754.5 Da
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