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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

Category: Neurodegenerative Diseases
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942 Results
  • ω-Conotoxin CVIE
    Bioassay Tested
    ω-Conotoxin CVIE
    A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Product Code: STC-760
    • Short Description: A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 2639 Da
  • ω-Conotoxin MVIID
    Bioassay Tested
    ω-Conotoxin MVIID
    A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Product Code: STC-751
    • Short Description: A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • CAS No.: 153887-08-2
    • MW: 2695 Da
  • ω-Conotoxin CVIA
    Bioassay Tested
    ω-Conotoxin CVIA
    A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Product Code: STC-750
    • Short Description: A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 2642 Da
  • µ-Conotoxin BuIIIB
    Bioassay Tested
    µ-Conotoxin BuIIIB
    A potent blocker of NaV1.3 and NaV1.4 sodium channels that also inhibits NaV1.1 and NaV1.2 subtypes
    • Product Code: STC-661
    • Short Description: A potent blocker of NaV1.3 and NaV1.4 sodium channels that also inhibits NaV1.1 and NaV1.2 subtypes
    • Applications: Electrophysiology
    • MW: 2763 Da
  • κ-Conotoxin RIIIJ
    Bioassay Tested
    κ-Conotoxin RIIIJ
    A potent blocker that is highly selective for heteromeric KV1.2/KV1.1 and KV1.2/KV1.6 potassium channels
    • Product Code: STC-660
    • Short Description: A potent blocker that is highly selective for heteromeric KV1.2/KV1.1 and KV1.2/KV1.6 potassium channels
    • Applications: Electrophysiology
    • MW: 2807 Da
  • κ-Conotoxin RIIIK
    Bioassay Tested
    κ-Conotoxin RIIIK
    A specific potent blocker of KV1.2 K+ channels
    • Product Code: STC-650
    • Short Description: A specific potent blocker of KV1.2 K+ channels
    • Applications: Electrophysiology
    • CAS No.: 740843-55-4
    • MW: 2649 Da
  • α-Conotoxin LtIA
    Bioassay Tested
    α-Conotoxin LtIA
    A potent and selective antagonist of the α3/β2 nicotinic acetylcholine receptor (nAChR)
    • Product Code: STC-550
    • Short Description: A potent and selective antagonist of the α3/β2 nicotinic acetylcholine receptor (nAChR)
    • Applications: Electrophysiology
    • MW: 1601.9 Da
  • µ-Conotoxin BuIIIA
    Bioassay Tested
    µ-Conotoxin BuIIIA
    A potent blocker of neuronal NaV1.2 and skeletal muscle NaV1.4 voltage-gated sodium channels
    • Product Code: STC-540
    • Short Description: A potent blocker of neuronal NaV1.2 and skeletal muscle NaV1.4 voltage-gated sodium channels
    • Applications: Electrophysiology
    • MW: 2751 Da
  • ω-Conotoxin SO3
    Bioassay Tested
    ω-Conotoxin SO3
    A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Product Code: STC-470
    • Short Description: A potent and selective blocker of neuronal N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • CAS No.: 441284-32-8
    • MW: 2561 Da
  • µ-Conotoxin SIIIA
    Bioassay Tested
    µ-Conotoxin SIIIA
    A potent blocker of neuronal NaV1.2 channels that also inhibits NaV1.4 and NaV1.6 channels
    • Product Code: STC-450
    • Short Description: A potent blocker of neuronal NaV1.2 channels that also inhibits NaV1.4 and NaV1.6 channels
    • Applications: Electrophysiology
    • MW: 2207.5 Da
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