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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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Category: Neurodegenerative Diseases
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942 Results
  • ω-Conotoxin CVIC
    Bioassay Tested
    ω-Conotoxin CVIC
    A potent blocker of N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels
    • Product Code: STC-420
    • Short Description: A potent blocker of N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels
    • Applications: Electrophysiology
    • MW: 2783 Da
  • ω-Conotoxin CVIB
    Bioassay Tested
    ω-Conotoxin CVIB
    A potent blocker of N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels
    • Product Code: STC-410
    • Short Description: A potent blocker of N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels
    • Applications: Electrophysiology
    • MW: 2710 Da
  • µ-Conotoxin PIIIA
    Bioassay Tested
    µ-Conotoxin PIIIA
    A potent blocker of the skeletal muscle voltage-gated sodium NaV1.4 channel that also inhibits other TTX-sensitive neuronal NaV channels
    • Product Code: STC-400
    • Short Description: A potent blocker of the skeletal muscle voltage-gated sodium NaV1.4 channel that also inhibits other TTX-sensitive neuronal NaV channels
    • Applications: Electrophysiology
    • MW: 2604 Da
  • Charybdotoxin
    Bioassay Tested
    Charybdotoxin
    A potent broad-spectrum blocker of K+ channels, including KV1.2, KV1.3, KV1.6, KCa1.1 and KCa3.1 channels
    • Product Code: STC-325
    • Applications: Electrophysiology
    • CAS No.: 95751-30-7
    • MW: 4296 Da
  • α-Conotoxin MrIC
    Bioassay Tested
    α-Conotoxin MrIC
    An α7 nAChR potent antagonist that functions as a PAM-dependent biased agonist
    • Product Code: STC-320
    • Short Description: An α7 nAChR potent antagonist that functions as a PAM-dependent biased agonist
    • Applications: Electrophysiology
    • MW: 1835 Da
  • α-Conotoxin AuIB
    Bioassay Tested
    α-Conotoxin AuIB
    An antagonist of mammalian α3/β4 neuronal nAChR that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Product Code: STC-310
    • Short Description: An antagonist of mammalian α3/β4 neuronal nAChR that also inhibits N-type (CaV2.2) calcium channels via GABA(B) receptor activation
    • Applications: Electrophysiology
    • CAS No.: 216299-21-7
    • MW: 1572.8 Da
  • Cd1a Toxin
    Bioassay Tested
    Cd1a Toxin
    A potent blocker of NaV1.7 voltage-gated sodium channels and modest blocker of N-type (CaV2.2) calcium channels
    • Product Code: STC-260
    • Short Description: A potent blocker of NaV1.7 voltage-gated sodium channels and modest blocker of N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 4030.6 Da
  • α-Conotoxin GeXIVA
    Bioassay Tested
    α-Conotoxin GeXIVA
    A potent antagonist of α9α10 nAChRs with negligible activity on other nAChR subtypes
    • Product Code: STC-220
    • Short Description: A potent antagonist of α9α10 nAChRs with negligible activity on other nAChR subtypes
    • Applications: Electrophysiology
    • CAS No.: 2010167-25-4
    • MW: 3453 Da
  • ω-Conotoxin Bu8
    Bioassay Tested
    ω-Conotoxin Bu8
    A potent and specific blocker of N-type (CaV2.2) calcium channels
    • Product Code: STC-180
    • Short Description: A potent and specific blocker of N-type (CaV2.2) calcium channels
    • Applications: Electrophysiology
    • MW: 2753 Da
  • ω-Conotoxin SVIB
    Bioassay Tested
    ω-Conotoxin SVIB
    A potent, reversible N-type (CaV2.2) and irreversible P/Q-type (CaV2.1) voltage-gated calcium channel blocker
    • Product Code: STC-160
    • Applications: Electrophysiology
    • MW: 2739 Da
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