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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

Category: Cardiovascular
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954 Results
  • Imperatoxin A
    Bioassay Tested
    Imperatoxin A
    A high-affinity activator/modulator of RYR1 and RYR3
    • Product Code: STI-333
    • Short Description: A high-affinity activator/modulator of RYR1 and RYR3
    • Applications: Muscle Physiology Assays, Electrophysiology, Calcium imaging assay
    • CAS No.: 172451-37-5
    • MW: 3758 Da
  • Hm1a Toxin
    Bioassay Tested
    Hm1a Toxin
    A potent and selective activator of NaV1.1 channels
    • Product Code: STH-601
    • Short Description: A potent and selective activator of NaV1.1 channels
    • Applications: Electrophysiology
    • MW: 3996.4 Da
  • Hj2a Toxin
    Bioassay Tested
    Hj2a Toxin
    A potent activator of multiple sodium channels (NaV1.1-NaV1.7)
    • Product Code: STH-555
    • Short Description: A potent activator of multiple sodium channels (NaV1.1-NaV1.7)
    • Applications: Electrophysiology
    • MW: 7118 Da
  • Heteropodatoxin-2
    Bioassay Tested
    Heteropodatoxin-2
    A potent blocker of KV4 K+ channels
    • Product Code: STH-340
    • Short Description: A potent blocker of KV4 K+ channels
    • Applications: Electrophysiology
    • MW: 3413 Da
  • Heteropodatoxin-1
    Bioassay Tested
    Heteropodatoxin-1
    An activator of NaV1.9 and an inhibitor of KV4.2 and NaV1.7
    • Product Code: STH-320
    • Short Description: An activator of NaV1.9 and an inhibitor of KV4.2 and NaV1.7
    • Applications: Electrophysiology
    • MW: 3910.4 Da
  • HsTx1 Toxin
    Bioassay Tested
    HsTx1 Toxin
    A potent blocker of KV1.3 K+ channels
    • Product Code: STH-300
    • Short Description: A potent blocker of KV1.3 K+ channels
    • Applications: Electrophysiology
    • MW: 3818.5 Da
  • GsAF-II
    Bioassay Tested
    GsAF-II
    A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Product Code: STG-350
    • Short Description: A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Applications: Electrophysiology
    • MW: 3979.8 Da
  • GsAF-I
    Bioassay Tested
    GsAF-I
    A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Product Code: STG-300
    • Short Description: A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Applications: Electrophysiology
    • MW: 3707.5 Da
  • GrTx1
    Bioassay Tested
    GrTx1
    A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Product Code: STG-250
    • Short Description: A potent gating modifier of tetrodotoxin-sensitive (TTX-s) neuronal voltage-gated sodium (NaV) channels that also blocks hERG1 potassium channels
    • Applications: Electrophysiology
    • MW: 3697.5 Da
  • Guangxitoxin-1E
    Bioassay Tested
    Guangxitoxin-1E
    A potent gating modifier of KV2.1 and KV2.2 K+ channels that also inhibits KV4.3 channels
    • Product Code: STG-200
    • Short Description: A potent gating modifier of KV2.1 and KV2.2 K+ channels that also inhibits KV4.3 channels
    • Applications: Electrophysiology
    • CAS No.: 1233152-82-3
    • MW: 3948.7 Da
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