Cell Surface-Binding Antibodies

Cell Surface-Binding Antibodies

Antibodies targeting extracellular epitopes for surface labeling and live-cell detection

Cell surface-binding antibodies are essential tools for studying membrane proteins in their native, physiological context. These in-house produced antibodies recognize extracellular epitopes of cell surface proteins, enabling live-cell labeling, flow cytometry, surface receptor tracking, and functional studies without the need for cell permeabilization.
Alomone Labs offers a comprehensive portfolio of highly specific, well-validated antibodies targeting extracellular domains of ion channels, receptors, and transporters. These antibodies are carefully designed to ensure epitope accessibility, specificity, and reproducibility across advanced imaging and cytometry workflows. Each antibody is rigorously validated in immunohistochemistry (IHC), immunocytochemistry (ICC), western blot (WB), and/or flow cytometry, with matched blocking peptides available to confirm specificity.

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FAQs

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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796 Results
  • Anti-5HT5B Receptor (HTR5B) (extracellular) Antibody
    Anti-5HT5B Receptor (HTR5B) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 5B
    • Product Code: ASR-040
    • Short Description: A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 5B
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot
    • Target: 5-Hydroxytryptamine receptor 5B, Serotonin receptor 5B, MR22
  • Anti-5HT6 Receptor (HTR6) (extracellular) Antibody
    Anti-5HT6 Receptor (HTR6) (extracellular) Antibody
    A Rabbit Polyclonal antibody to 5HT6 Receptor (HTR6) (extracellular).
    • Product Code: ASR-038
    • Short Description: A Rabbit Polyclonal antibody to 5HT6 Receptor (HTR6) (extracellular).
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6, 5-HT-6, 5HT6R
  • Anti-5HT7 Receptor/HTR7 (extracellular) Antibody
    Anti-5HT7 Receptor/HTR7 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to 5HT7 Receptor
    • Product Code: ASR-037
    • Short Description: A Rabbit Polyclonal Antibody to 5HT7 Receptor
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunofluorescence, Immunohistochemistry
    • Target: 5-Hydroxytryptamine Receptor 7, Serotonin Receptor 7, 5-HT7, 5-HT-7
  • Anti-5HT7 Receptor/HTR7 (extracellular)-FITC Antibody
    Anti-5HT7 Receptor/HTR7 (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to 5HT7 receptor (extracellular) conjugated to the fluorescent dye FITC
    • Product Code: ASR-037-F
    • Short Description: A Rabbit Polyclonal Antibody to 5HT7 receptor (extracellular) conjugated to the fluorescent dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: 5-Hydroxytryptamine Receptor 7, Serotonin Receptor 7, 5-HT7, 5-HT-7
  • Anti-ACE2 (extracellular) Antibody
    Anti-ACE2 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to ACE2 (extracellular)
    • Product Code: AAC-012
    • Short Description: A Rabbit Polyclonal Antibody to ACE2 (extracellular)
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunohistochemistry
    • Target: Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-converting enzyme homolog, ACEH, Metalloprotease MPROT15
  • Anti-ACE2 (extracellular)-FITC Antibody
    Anti-ACE2 (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to ACE2 (extracellular) conjugated to the fluorescent dye FITC
    • Product Code: AAC-012-F
    • Short Description: A Rabbit Polyclonal Antibody to ACE2 (extracellular) conjugated to the fluorescent dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-converting enzyme homolog, ACEH, Metalloprotease MPROT15
  • Anti-ACVRL1 (extracellular) Antibody
    Anti-ACVRL1 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to ACVRL1
    • Product Code: ABR-041
    • Short Description: A Rabbit Polyclonal Antibody to ACVRL1
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot
    • Target: Activin A Receptor Like Type 1, ALK1, Serine/Threonine-Protein Kinase Receptor R3, SKR3, TGF-B Superfamily Receptor Type I, TSR-I
  • Anti-ADAM10 (extracellular) Antibody
    Anti-ADAM10 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to ADAM10 (extracellular)
    • Product Code: ANR-156
    • Short Description: A Rabbit Polyclonal Antibody to ADAM10 (extracellular)
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunohistochemistry
    • Target: Disintegrin And Metalloproteinase Domain-Containing Protein 10, ADAM Metallopeptidase Domain 10, CD156c
  • Anti-ADAM10 (extracellular)-FITC Antibody
    Anti-ADAM10 (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to ADAM10 (extracellular) conjugated to the fluorescent dye FITC
    • Product Code: ANR-156-F
    • Short Description: A Rabbit Polyclonal Antibody to ADAM10 (extracellular) conjugated to the fluorescent dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: Disintegrin And Metalloproteinase Domain-Containing Protein 10, ADAM Metallopeptidase Domain 10, CD156c
  • Anti-ADAM22 (extracellular) Antibody
    Anti-ADAM22 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to ADAM22
    • Product Code: ANR-120
    • Short Description: A Rabbit Polyclonal Antibody to ADAM22
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Disintegrin and metalloproteinase domain-containing protein 22, ADAM metallopeptidase domain 22, MDC2
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