Cell Surface-Binding Antibodies

Cell Surface-Binding Antibodies

Antibodies targeting extracellular epitopes for surface labeling and live-cell detection

Cell surface-binding antibodies are essential tools for studying membrane proteins in their native, physiological context. These in-house produced antibodies recognize extracellular epitopes of cell surface proteins, enabling live-cell labeling, flow cytometry, surface receptor tracking, and functional studies without the need for cell permeabilization.
Alomone Labs offers a comprehensive portfolio of highly specific, well-validated antibodies targeting extracellular domains of ion channels, receptors, and transporters. These antibodies are carefully designed to ensure epitope accessibility, specificity, and reproducibility across advanced imaging and cytometry workflows. Each antibody is rigorously validated in immunohistochemistry (IHC), immunocytochemistry (ICC), western blot (WB), and/or flow cytometry, with matched blocking peptides available to confirm specificity.

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FAQs

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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799 Results
  • Anti-GnRH Receptor (extracellular) Antibody
    Anti-GnRH Receptor (extracellular) Antibody
    A Rabbit Polyclonal Antibody to GnRH Receptor
    • Product Code: AGR-030
    • Short Description: A Rabbit Polyclonal Antibody to GnRH Receptor
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Gonadotropin-releasing hormone receptor, GnRHR, Leutinizing hormone releasing hormone receptor, LHRHR, Luliberin receptor
  • Anti-GP130 (extracellular) Antibody
    Anti-GP130 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to GP130
    • Product Code: ALR-023
    • Short Description: A Rabbit Polyclonal Antibody to GP130
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Western blot, Immunohistochemistry
    • Target: Interleukin-6 receptor subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Oncostatin-M receptor subunit alpha, CD130, Il6st
  • Anti-GPER1/GPR30 (extracellular) Antibody
    Anti-GPER1/GPR30 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to GPER1/GPR30
    • Product Code: AER-049
    • Short Description: A Rabbit Polyclonal Antibody to GPER1/GPR30
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Western blot
    • Target: G protein-coupled estrogen receptor 1, G protein-coupled receptor 30, Membrane estrogen receptor, Chemoattractant receptor-like 2, GPER
  • Anti-GPER1/GPR30 (extracellular) Antibody-APC Antibody
    Anti-GPER1/GPR30 (extracellular) Antibody-APC Antibody
    A Rabbit Polyclonal Antibody to GPER1 (extracellular) conjugated to Allophycocyanin (APC) fluorophore.
    • Product Code: AER-049-APC
    • Short Description: A Rabbit Polyclonal Antibody to GPER1 (extracellular) conjugated to Allophycocyanin (APC) fluorophore.
    • Host: Rabbit
    • Label: APC
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: GPER1
  • Anti-GPER1/GPR30 (extracellular)-FITC Antibody
    Anti-GPER1/GPR30 (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to GPER1 Conjugated to the Fluorescent Dye FITC
    • Product Code: AER-049-F
    • Short Description: A Rabbit Polyclonal Antibody to GPER1 Conjugated to the Fluorescent Dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human, Rat, Mouse
    • Applications: Flow cytometry
    • Target: G Protein-Coupled Estrogen Receptor 1, G Protein-Coupled Receptor 30, Membrane Estrogen Receptor, Chemoattractant Receptor-Like 2, GPER
  • Anti-GPR108 (extracellular) Antibody
    Anti-GPR108 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to GPR108 (extracellular)
    • Product Code: AGR-088
    • Short Description: A Rabbit Polyclonal Antibody to GPR108 (extracellular)
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunohistochemistry
    • Target: G-Protein Coupled Receptor 108, Lung Seven Transmembrane Receptor 2, LUSTR2
  • Anti-GPR109A/HCAR2 (extracellular) Antibody
    Anti-GPR109A/HCAR2 (extracellular) Antibody
    A Rabbit Polyclonal antibody to GPR109A/HCAR2 (extracellular)
    • Product Code: AHR-012
    • Short Description: A Rabbit Polyclonal antibody to GPR109A/HCAR2 (extracellular)
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunohistochemistry
    • Target: Hydroxycarboxylic Acid Receptor 2, Niacin Receptor 1, G-Protein Coupled Receptor HM74A, HM74A, Nicotinic acid receptor, PUMAG
  • Anti-GPR109A/HCAR2 (extracellular)-FITC Antibody
    Anti-GPR109A/HCAR2 (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to GPR109A/HCAR2 (extracellular) conjugated to the fluorescent dye FITC
    • Product Code: AHR-012-F
    • Short Description: A Rabbit Polyclonal Antibody to GPR109A/HCAR2 (extracellular) conjugated to the fluorescent dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: Hydroxycarboxylic Acid Receptor 2, Niacin Receptor 1, G-Protein Coupled Receptor HM74A, HM74A, Nicotinic acid receptor, PUMAG
  • Anti-GPR12 (extracellular) Antibody
    Anti-GPR12 (extracellular) Antibody
    A Rabbit Polyclonal antibody to SORCS2
    • Product Code: AGR-062
    • Short Description: A Rabbit Polyclonal antibody to SORCS2
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: G-Protein Coupled Receptor 12, GPCR21
  • Anti-GPR120/FFAR4 (extracellular) Antibody
    Anti-GPR120/FFAR4 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to Free Fatty Acid Receptor 4 (GPR120)
    • Product Code: AFR-014
    • Short Description: A Rabbit Polyclonal Antibody to Free Fatty Acid Receptor 4 (GPR120)
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunohistochemistry
    • Target: G-protein coupled receptor 120, Free fatty acid receptor 4, FFA4 Receptor, G-protein coupled receptor GT01, Omega-3 fatty acid receptor 1, O3far1
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