Cell Surface-Binding Antibodies

Cell Surface-Binding Antibodies

Antibodies targeting extracellular epitopes for surface labeling and live-cell detection

Cell surface-binding antibodies are essential tools for studying membrane proteins in their native, physiological context. These in-house produced antibodies recognize extracellular epitopes of cell surface proteins, enabling live-cell labeling, flow cytometry, surface receptor tracking, and functional studies without the need for cell permeabilization.
Alomone Labs offers a comprehensive portfolio of highly specific, well-validated antibodies targeting extracellular domains of ion channels, receptors, and transporters. These antibodies are carefully designed to ensure epitope accessibility, specificity, and reproducibility across advanced imaging and cytometry workflows. Each antibody is rigorously validated in immunohistochemistry (IHC), immunocytochemistry (ICC), western blot (WB), and/or flow cytometry, with matched blocking peptides available to confirm specificity.

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FAQs

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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799 Results
  • Anti-KCNK16 (TALK-1) (extracellular) Antibody
    KO Validate'
    Anti-KCNK16 (TALK-1) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to KCNK16 Channel
    • Product Code: APC-170
    • Short Description: A Rabbit Polyclonal Antibody to KCNK16 Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: Potassium two pore domain channel subfamily K member 16, TWIK-related alkaline pH-activated K+ channel 1, K2P16.1
  • Anti-KCNK18 (TRESK) (extracellular) Antibody
    Anti-KCNK18 (TRESK) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to KCNK18 Channel
    • Product Code: APC-122
    • Short Description: A Rabbit Polyclonal Antibody to KCNK18 Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: Potassium channel subfamily K member 18, TWIK-related spinal cord K+ channel, K2P18.1
  • Anti-KCNK9 (TASK-3) (extracellular) Antibody
    Anti-KCNK9 (TASK-3) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to KCNK9 Channel 
    • Product Code: APC-044
    • Short Description: A Rabbit Polyclonal Antibody to KCNK9 Channel 
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Potassium channel subfamily K member 9, K2P9.1, TWIK-related acid-sensitive K+ channel 3, Two pore K+ channel KT3.2
  • Anti-KCNMA1 (K<sub>Ca</sub>1.1) (extracellular) Antibody
    Anti-KCNMA1 (KCa1.1) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to KCNMA1 (KCa1.1) Channel
    • Product Code: APC-151
    • Short Description: A Rabbit Polyclonal Antibody to KCNMA1 (KCa1.1) Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Large conductance calcium-activated potassium channel subfamily M subunit alpha-1, BKCa alpha, Maxi K+, Slo1
  • Anti-KCNQ1 (extracellular) Antibody
    Anti-KCNQ1 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to KCNQ1 (KV7.1) Channel
    • Product Code: APC-168
    • Short Description: A Rabbit Polyclonal Antibody to KCNQ1 (KV7.1) Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence
    • Target: KV7.1, Voltage-gated potassium channel QKT subfamily member 1, KvLQT1, KCNA9
  • Anti-KCNQ1 (extracellular)-ATTO Fluor-647N Antibody
    Anti-KCNQ1 (extracellular)-ATTO Fluor-647N Antibody
    A Rabbit Polyclonal Antibody to KV7.1 (extracellular) conjugated to the fluorescent dye ATTO Fluor-647N.
    • Product Code: APC-168-FRN
    • Short Description: A Rabbit Polyclonal Antibody to KV7.1 (extracellular) conjugated to the fluorescent dye ATTO Fluor-647N.
    • Host: Rabbit
    • Label: ATTO 647N
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry, Immunohistochemistry
    • Target: Kcnq1
  • Anti-KCNQ1 (extracellular)-FITC Antibody
    Anti-KCNQ1 (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to KV7.1 (extracellular) conjugated to the fluorescent dye FITC
    • Product Code: APC-168-F
    • Short Description: A Rabbit Polyclonal Antibody to KV7.1 (extracellular) conjugated to the fluorescent dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: KV7.1, Voltage-gated potassium channel QKT subfamily member 1, KvLQT1, KCNA9
  • Anti-KCNS1 (K<sub>V</sub>9.1) (extracellular) Antibody
    Anti-KCNS1 (KV9.1) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to KCNS1 (KV9.1) Channel
    • Product Code: APC-131
    • Short Description: A Rabbit Polyclonal Antibody to KCNS1 (KV9.1) Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot
    • Target: Potassium voltage-gated channel subfamily S member 1
  • Anti-KCNS3 (K<sub>V</sub>9.3) (extracellular) Antibody
    Anti-KCNS3 (KV9.3) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to KCNS3 (KV9.3) Channel
    • Product Code: APC-133
    • Short Description: A Rabbit Polyclonal Antibody to KCNS3 (KV9.3) Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Potassium voltage-gated channel subfamily S member 3
  • Anti-K<sub>ir</sub>2.1/KCNJ2 (extracellular) Antibody
    Anti-Kir2.1/KCNJ2 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to Kir2.1 (KCNJ2) Channel
    • Product Code: APC-159
    • Short Description: A Rabbit Polyclonal Antibody to Kir2.1 (KCNJ2) Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: Inward rectifier potassium channel 2, IRK1, HIRK1, LQT7, SQT3
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