Cell Surface-Binding Antibodies

Cell Surface-Binding Antibodies

Antibodies targeting extracellular epitopes for surface labeling and live-cell detection

Cell surface-binding antibodies are essential tools for studying membrane proteins in their native, physiological context. These in-house produced antibodies recognize extracellular epitopes of cell surface proteins, enabling live-cell labeling, flow cytometry, surface receptor tracking, and functional studies without the need for cell permeabilization.
Alomone Labs offers a comprehensive portfolio of highly specific, well-validated antibodies targeting extracellular domains of ion channels, receptors, and transporters. These antibodies are carefully designed to ensure epitope accessibility, specificity, and reproducibility across advanced imaging and cytometry workflows. Each antibody is rigorously validated in immunohistochemistry (IHC), immunocytochemistry (ICC), western blot (WB), and/or flow cytometry, with matched blocking peptides available to confirm specificity.

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FAQs

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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799 Results
  • Guinea pig Anti-GluR3 (GluA3) (extracellular) Antibody
    Guinea pig Anti-GluR3 (GluA3) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to AMPA-Selective Glutamate Receptor 3 (GluR3)
    • Product Code: AGC-010-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to AMPA-Selective Glutamate Receptor 3 (GluR3)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: AMPA receptor 3, Glutamate receptor 3, Ionotropic glutamate receptor 3, AMPA-selective glutamate receptor 3, GRIA3, GluR-C, GluR-K3
  • Guinea pig Anti-K<sub>V</sub>1.3 (KCNA3) (extracellular) Antibody
    Guinea pig Anti-KV1.3 (KCNA3) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to KV1.3 (KCNA3) Channel
    • Product Code: APC-101-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to KV1.3 (KCNA3) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Potassium voltage-gated channel subfamily A member 3
  • Guinea pig Anti-mGluR5 (extracellular) Antibody
    Guinea pig Anti-mGluR5 (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to Metabotropic Glutamate Receptor 5
    • Product Code: AGC-007-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Metabotropic Glutamate Receptor 5
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot
    • Target: Metabotropic glutamate receptor 5, GRM5, mGlu5, GPRC1E
  • Guinea Pig Anti-Nicotinic Acetylcholine Receptor α6 (CHRNA6) (extracellular) Antibody
    Guinea Pig Anti-Nicotinic Acetylcholine Receptor α6 (CHRNA6) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to Nicotinic Acetylcholine Receptor α6
    • Product Code: ANC-006-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Nicotinic Acetylcholine Receptor α6
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot
    • Target: nAChR α6, Cholinergic receptor nicotinic alpha 6, Neuronal acetylcholine receptor subunit alpha-6, ACRA6
  • Guinea Pig Anti-Nicotinic Acetylcholine Receptor α7 (CHRNA7) (extracellular) Antibody
    Guinea Pig Anti-Nicotinic Acetylcholine Receptor α7 (CHRNA7) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to Nicotinic Acetylcholine Receptor α7 (CHRNA7) (extracellular)
    • Product Code: ANC-007-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Nicotinic Acetylcholine Receptor α7 (CHRNA7) (extracellular)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: nAChR α7, Cholinergic receptor nicotinic alpha 7, Neuronal acetylcholine receptor subunit alpha-7, ACRA7
  • Guinea pig Anti-NMDAR1 (GluN1) (extracellular) Antibody
    Guinea pig Anti-NMDAR1 (GluN1) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to NMDA Receptor 1 (GluN1)
    • Product Code: AGC-001-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to NMDA Receptor 1 (GluN1)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: NMDA receptor 1, Ionotropic glutamate receptor subunit ζ 1, N-methyl-D-aspartate receptor subunit 1, GRIN1
  • Guinea pig Anti-P2Y12 Receptor (extracellular) Antibody
    Guinea pig Anti-P2Y12 Receptor (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to P2Y12 Receptor
    • Product Code: APR-020-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to P2Y12 Receptor
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: P2Y purinoceptor 12, P2RY12, ADP-glucose receptor, Platelet ADP receptor, HORK3
  • Guinea Pig Anti-TrkB (extracellular) Antibody
    Guinea Pig Anti-TrkB (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to TrkB
    • Product Code: ANT-019-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to TrkB
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: Neurotrophic tyrosine kinase receptor type 2, NTRK2, BDNF/NT-3 growth factors receptor, TrkB Tyrosine Kinase
  • Guinea Pig Anti-TRPA1 (extracellular) Antibody
    Guinea Pig Anti-TRPA1 (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to TRPA1 (extracellular)
    • Product Code: ACC-037-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to TRPA1 (extracellular)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: Transient receptor potential cation channel subfamily A member 1, ANKTM1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120, Wasabi Receptor
  • Guinea pig Anti-TRPV2 (VRL1) (extracellular) Antibody
    Guinea pig Anti-TRPV2 (VRL1) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to TRPV2 (VRL1) Channel
    • Product Code: ACC-039-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to TRPV2 (VRL1) Channel
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: Transient receptor potential cation channel subfamily V member 2, Vanilloid receptor-like protein 1, VRL-1, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, SAC2B
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