Cell Surface-Binding Antibodies

Cell Surface-Binding Antibodies

Antibodies targeting extracellular epitopes for surface labeling and live-cell detection

Cell surface-binding antibodies are essential tools for studying membrane proteins in their native, physiological context. These in-house produced antibodies recognize extracellular epitopes of cell surface proteins, enabling live-cell labeling, flow cytometry, surface receptor tracking, and functional studies without the need for cell permeabilization.
Alomone Labs offers a comprehensive portfolio of highly specific, well-validated antibodies targeting extracellular domains of ion channels, receptors, and transporters. These antibodies are carefully designed to ensure epitope accessibility, specificity, and reproducibility across advanced imaging and cytometry workflows. Each antibody is rigorously validated in immunohistochemistry (IHC), immunocytochemistry (ICC), western blot (WB), and/or flow cytometry, with matched blocking peptides available to confirm specificity.

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FAQs

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

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799 Results
  • Anti-κ-Opioid Receptor (OPRK1) (extracellular)-FITC Antibody
    Anti-κ-Opioid Receptor (OPRK1) (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to ?-Opioid Receptor (extracellular) conjugated to the fluorescent dye FITC
    • Product Code: AOR-012-F
    • Short Description: A Rabbit Polyclonal Antibody to ?-Opioid Receptor (extracellular) conjugated to the fluorescent dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: Kappa-type opioid receptor, KOR-1, KOR, Opiate receptor kappa 1
  • Guinea Pig Anti-5HT2A Receptor (HTR2A) (extracellular) Antibody
    Guinea Pig Anti-5HT2A Receptor (HTR2A) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to 5-HT2A Receptor
    • Product Code: ASR-033-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to 5-HT2A Receptor
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: 5-Hydroxytryptamine receptor 2A, Serotonin receptor 2A, 5-HT2A
  • Guinea Pig Anti-Cannabinoid Receptor 1 (extracellular) Antibody
    Guinea Pig Anti-Cannabinoid Receptor 1 (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to Cannabinoid Receptor 1 (extracellular)
    • Product Code: ACR-001-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Cannabinoid Receptor 1 (extracellular)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: CB1, CB-R, CB1R, CANN6, Brain-type cannabinoid receptor, Central cannabinoid receptor, CNR1
  • Guinea Pig Anti-Dopamine Transporter (DAT) (extracellular) Antibody
    Guinea Pig Anti-Dopamine Transporter (DAT) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to Dopamine Transporter (DAT)
    • Product Code: AMT-003-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Dopamine Transporter (DAT)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: Sodium-dependent dopamine transporter, DA transporter, Solute carrier family 6 member 3, SLC6A3
  • Guinea Pig Anti-EAAT2 (GLT-1) (extracellular) Antibody
    Guinea Pig Anti-EAAT2 (GLT-1) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to Excitatory Amino Acid Transporter 2 (EAAT2, GLT-1)
    • Product Code: AGC-022-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to Excitatory Amino Acid Transporter 2 (EAAT2, GLT-1)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: Excitatory amino acid transporter 2, Sodium-dependent glutamate/aspartate transporter 2, Glutamate/Aspartate Transporter II, Solute Carrier Family 1 Member 2, SLC1A2
  • Guinea pig Anti-EMR1 (ADGRE1) (extracellular) Antibody
    Guinea pig Anti-EMR1 (ADGRE1) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to EMR1
    • Product Code: AER-051-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to EMR1
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot
    • Target: MR1 hormone receptor, EGF-like module-containing mucin-like hormone receptor-like 1, Adhesion G protein-coupled receptor E1, TM7LN3, F4/80, GPF480
  • Guinea Pig Anti-GABA Transporter 1 (GAT-1) (extracellular) Antibody
    Guinea Pig Anti-GABA Transporter 1 (GAT-1) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to GABA Transporter 1 (GAT-1) (extracellular)
    • Product Code: AGT-001-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to GABA Transporter 1 (GAT-1) (extracellular)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: GABATR, GABT1, GABATHG, Na+/Cl-- dependent GABA transporter 1, Solute Carrier Family 6 Member 1, SLC6A1
  • Guinea pig Anti-GABA(A) α1 Receptor (extracellular) Antibody
    Guinea pig Anti-GABA(A) α1 Receptor (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to GABA(A) α1 Receptor
    • Product Code: AGA-001-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to GABA(A) α1 Receptor
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: γ-Aminobutyric acid receptor type A subunit α1, GABRA1
  • Guinea pig Anti-GluR1 (GluA1) (extracellular) Antibody
    Guinea pig Anti-GluR1 (GluA1) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to AMPA-Selective Glutamate Receptor 1 (GluR1)
    • Product Code: AGC-004-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to AMPA-Selective Glutamate Receptor 1 (GluR1)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: AMPA Receptor 1, Glutamate receptor 1, Ionotropic glutamate receptor 1, AMPA-selective glutamate receptor 1, GRIA1, GluR-A, GluR-K1
  • Guinea pig Anti-GluR2 (GluA2) (extracellular) Antibody
    Guinea pig Anti-GluR2 (GluA2) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to AMPA-Selective Glutamate Receptor 2 (GluR2)
    • Product Code: AGC-005-GP
    • Short Description: A Rabbit Polyclonal Antibody to AMPA-Selective Glutamate Receptor 2 (GluR2)
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence
    • Target: AMPA receptor 2, Glutamate receptor 2, Ionotropic glutamate receptor 2, AMPA-selective glutamate receptor 2, GRIA2, GluR-B, GluR-K2
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