Modulator

Issue No. 22

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K+ Channels in Cardiomyocytes

The contribution and importance of K+ channels to the normal activity of the heart is best exemplified by disturbances in the activity of one K+ channel, causing cardiac arrhythmia. This voltage dependent cardiac K+ channel is called hERG (KV11.1) and both mutations in the gene encoding this …

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The Involvement of Ion Channels in Cell Proliferation

The control of cell proliferation involves diverse signaling pathways, growth factors, and receptors. The involvement of ion channels in this process is supported by a wealth of experimental evidence with mechanisms not always well understood. However, the emerging roles ion channels play in such …

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The Transient Receptor Potential Superfamily: Antibodies in Action

The transient receptor potential (TRP) superfamily, one of the largest ion channel families, consists of a diverse group of proteins. The mammalian TRP superfamily comprises six subfamilies known as TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipins), TRPP (polycystin), and …

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The Role of Ion Channels in Neurodegeneration

Neurodegenerative diseases take an enormous toll on society as well as on individuals. Very limited treatments for these diseases exist, since their molecular mechanisms are not well understood. Several ion channels, a group of membrane spanning proteins that regulate ion content and membrane …

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Ion Channels and Oxygen Sensing in the Carotid Body

Oxygen is an absolute requirement of all mammalian cells. Practically every cell is able to sense a decrease in oxygen tension and responds by regulating the expression and/or function of several genes that, in a matter of hours or days, reduce oxygen dependency. However, at the organismal level, a …

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