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Neurotrophin Pathways

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proNGF and proBDNF: The Alter Egos

Neurotrophins, like many growth factors, are expressed as precursor proteins which are then truncated and further modified to yield the mature form. The presence of highly conserved sequences in the prodomain of different neurotrophins made it clear that the prodomain must have some biological …


NGF: One Molecule, Multiple Functions

Nerve Growth Factor (NGF) is one of the founding and best-characterized members of the neurotrophin family. This family comprises a unique collection of polypeptidic growth factors that promote the proliferation, differentiation, survival and death of neuronal and non-neuronal cells. Alomone Labs …


BDNF – Second Best?

Brain Derived Neurotrophic Factor (BDNF) is the second best characterized neurotrophin (following NGF) and acts as a key contributor to neuronal development as well as neuronal plasticity. BDNF is a homo-dimer protein which is secreted to affect cells that express the BDNF receptors - TrkB and p75


p75NTR – The Promiscuous Receptor

The p75 neurotrophin receptor (p75NTR) could bind a variety of proteins all with biological significance. While this receptor has no catalytic activities, and therefore influences cellular outcomes through protein-protein interactions, how it controls one cellular event over another remains to be …


GDNF – a Neurotrophic Survival Factor

Glial-Derived Neurotrophic Factor (GDNF) is the major member of the GDNF family protein which is distantly related to the TGF-β superfamily. GDNF elicits its cellular and physiological effects by binding RET, a tyrosine receptor kinase and GPI-linked co-receptors, belonging to the GDNF receptor α …