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α-Melanotropin, alpha-MSH

A Ligand of Melanocortin G-Protein Coupled Receptor

Cat #: GPM-100
Alternative Name α-Melanotropin, alpha-MSH
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1665 Da
    Purity: >98% (HPLC)
    Effective concentration 30-300 pM.
    Modifications Ser1- Acetylation. Val13- C-terminal amidation.
    Molecular formula C77H109N21O19S.
    CAS No.: 581-05-5
    Activity α-MSH is involved in food intake regulation, energy homeostasis, immune responses modulation and photoprotection1-3.
    1. Slominski, A. and Wortsman, J. (2000) Endocr. Rev. 21, 457.
    2. Yeo, G.S. et al. (2000) QJM 93, 7.
    3. Ohguchi, K. et al. (2004) J. Biol. Chem. 279, 3408.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs α-MSH induces melanogenesis in B16 melanoma cells.
      Alomone Labs α-MSH induces melanogenesis in B16 melanoma cells.
      Cells were incubated with increasing concentrations of α-MSH (#GPM-100). Melanin production was measured after 3 days and plotted against α-MSH concentrations (ED50 = 67 ng/ml, upper graph). Below the graph is a visual representation of melanin production intensity following α-MSH stimulation for three days.
    References - Scientific background
    1. Lerner, A.B. et al. (1954) AMA Arch. Derm. Syphilol70, 669.
    2. Pritchard, L.E, and White, A. (2007) Endocrinology 148, 4201.
    3. Nakanishi, S. et al. (1979) Nature 278, 423.
    4. Tsatmali, T. et al. (2002) J. Histochem. Cytochem. 50, 125.
    5. Bloomgarden, Z. T. (2002) Diabetes Care. 25, 789.
    6. Catania, A. et al. (2004) Pharmacol. Rev. 56, 1.
    7. Böhm, M. et al. (2006) Cell. Mol. Biol. 52, 61.
    Scientific background

    α-MSH is a neuropeptide originally isolated from the pituitary gland1. α-MSH is produced by post-translational processing of a precursor protein, proopiomelanocortin (POMC)2. In most vertebrates but not in mammals, α-MSH is produced in the intermediate lobe of the pituitary gland. The biological activities of α-MSH are mediated through a family of five specific G-protein coupled receptors: MCR1, MCR2, MCR3, MCR4, and MCR5. α-MSH is an evolutionarily highly conserved peptide action that induces pigment dispersion in skin melanocytes of amphibians, reptiles and mammals by stimulating melanin production3,4.

    However, in human and other mammals, α-MSH acts in the brain in appetite suppression and sexual arousal. Some cases of extreme obesity have been traced to mutated α-MSH receptor in the brain. Presumably, these people are unable to respond to the appetite-suppressing effect of α-MSH5. α-MSH has significant anti-inflammatory properties, mediated through its binding to MCR16 and includes regulation of expression and secretion of chemokines, downregulation of proinflammatory signal-induced NF-kB activation and adhesion molecule expression, prostaglandin E2 synthesis, as well as induction of interleukin-107.

    Target Melanocortin receptor
    Net Peptide Content: 100%
    Last update: 11/04/2021

    α-MSH (#GPM-100) is a highly pure, synthetic, and biologically active protein.

    For research purposes only, not for human use
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