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αC-Conotoxin PrXA

αC-PrXA

A Potent Antagonist of Mammalian Muscle nAChR

Cat #: STC-620
Alternative Name αC-PrXA
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 3545 Da
    Purity: >98% (HPLC)
    Effective concentration 1-20 nM.
    Sequence TYGIYDAKPXFSCAGLRGGCVLPXNLRXKFKE.
    Modifications Disulfide bond between Cys13-Cys20. X = Hydroxyproline. Glu32 - C-terminal amidation.
    Structure
    Molecular formula C160H249N42O45S2.
    Activity αC-Conotoxin PrXA reversibly blocks both adult and fetal mammalian muscle α1/β1/ε/δ and α1/β1/γ/δ nicotinic ACh receptor1.
    References-Activity
    1. Jimenez, E.C. et al. (2007) Biochemistry 46, 8717.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs αC-Conotoxin PrXA inhibits muscle α1/β1/γ/δ nAChR heterologously expressed in Xenopus oocytes.
      Alomone Labs αC-Conotoxin PrXA inhibits muscle α1/β1/γ/δ nAChR heterologously expressed in Xenopus oocytes.
      A. Time course of αC-Conotoxin PrXA (#STC-620) action on muscle α1/β1/γ/δ nAChR. Current amplitudes were plotted as a function of time. Membrane potential was held at –80 mV and oocytes were stimulated by exposure to 100 μM acetylcholine every 100 seconds. 20 nM (for 6 min) αC-Conotoxin PrXA were perfused during the period marked by the bar, as indicated. B. Superimposed traces of muscle nAChR channel current in the absence (black) and presence (green) of 20 nM αC-Conotoxin PrxA (taken from the experiment in A).
    References - Scientific background
    1. Jimenez, E.C. et al. (2007) Biochemistry 46, 8717.
    Scientific background αC-Conotoxin PrXA is a synthetic peptide purified to homogeneity, originally isolated from the Conus parius venom1. αC-Conotoxin PrXA reversibly blocks both adult and fetal mammalian muscle α1/β1/ε/δ and α1/β1/γ/δ nicotinic ACh receptors1.
    Target α1/β1/γ/δ nAChR
    Net Peptide Content: 100%
    Lyophilized Powder
    Last update: 08/06/2021

    αC-Conotoxin PrXA (#STC-620) is a highly pure, synthetic, and biologically active peptide toxin.

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    For research purposes only, not for human use

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