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- Peptide (C)EQVPESISNQKRGVK, corresponding to amino acid residues 99 -113 of mouse β1-syntrophin (Accession Q99L88). Intracellular, PH1 domain.
- Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain membranes:1,2. Anti-β1-Syntrophin (SNTB1) Antibody (#APZ-022), (1:500).
3,4. Anti-β1-Syntrophin (SNTB1) Antibody, preincubated with the negative control antigen.Western blot analysis of human HL-60 promyelocytic leukemia cell line lysate (lanes 1 and 3) and human HepG2 hepatocellular carcinoma cell line lysate (lanes 2 and 4):1,2. Anti-β1-Syntrophin (SNTB1) Antibody (#APZ-022), (1:500).
3,4. Anti-β1-Syntrophin (SNTB1) Antibody, preincubated with the negative control antigen.
Syntrophins are a family of five membrane associated adaptor proteins with a molecular weight of 58-60 kDa. Adaptor proteins play a crucial role in coordinating signaling events and may act as rescuers in situations where a subversion from normal signaling exists. Syntrophins are characterized by the presence of a PDZ (postsynaptic density protein-95/disc large/zona occludens-1) split PH (pleckstrin homology) domain and a SU (syntrophin unique) domain within their structure.
β-1 Syntrophin is a 538 amino acid long protein while β-2 is 540 amino acid in length. Both forms are ubiquitously expressed in mammalian tissues however β-1 is the predominant form. β-1 Syntrophin is the basic form of the protein while α-1 is acidic. Like all forms of syntrophin, β-1 syntrophin may exist as a monomer or dimer within the cell. Almost all isoforms of syntrophin bind to each other.
Syntrophin is required for the proper localization expression and function of NaV1.4 and NaV1.5 Na+ channels. Both channels take part of a multi-protein complex in which dystrophin and syntrophin proteins play an important role in determining their expression levels. NaV1.4 and NaV1.5 C-termini consist of the PDZ domain-binding motif formed by the last three residues. The C-terminus of NaV1.5 thus binds with the dystrophin of DGC and this interaction is mediated by and β-syntrophin (and α-syntrophin) proteins1.
Syntrophin binds directly to dystrophin at the vicinity of dystrophin’s GPC binding site. Another low affinity binding site is presumed to exist at the COOH-terminal region of dystrophin2.
Species reactivity key:
Anti-β1-Syntrophin (SNTB1) Antibody (#APZ-022) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize SNTB1 from human, mouse, and rat samples.
- Anti-α1-Syntrophin (SNTA1) Antibody (#APZ-021)
- Anti-SCN4A (NaV1.4) Antibody (#ASC-020)
- Anti-NaV1.5 (SCN5A) (493-511) Antibody (#ASC-005)
- Guinea pig Anti-NaV1.5 (SCN5A) Antibody (#AGP-008)
- Anti-NaV1.5 (SCN5A) (1978-2016) Antibody (#ASC-013)
- Anti-PSD-93 Antibody (#APZ-002)
- Anti-PSD-95 Antibody (#APZ-009)
- Anti-SAP-97/DLG1 Antibody (#APZ-010)