- Peptide (C)RKRGEFRRKYRFSAD, corresponding to amino acid residues 43-57 of rat KCNK15 (Accession Q8R5I0). 1st extracellular loop.
- Western blot analysis of mouse brain lysates (lanes 1 and 3) and rat brain lysates (lanes 2 and 4):1,2. Anti-KCNK15 (TASK-5) (extracellular) Antibody (#APC-158), (1:200).
3,4. Anti-KCNK15 (TASK-5) (extracellular) Antibody, preincubated with KCNK15/TASK-5 (extracellular) Blocking Peptide (#BLP-PC158).
TASK1-5 are members of the two-pore domain K+ channels. They have four transmembrane domains and assist in setting the resting membrane potential.
TASK5 (K2P15.1, KCNK15) was identified using the TASK-3 sequence in a GenBank search. However, when expressed in COS-7 cells, it does not form a functional K+ current1.
The channel is distributed in the brain, heart, lung, kidney, liver, pancreas, adrenal gland and placenta2.
Species reactivity key:
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the rat KCNK15 channel. Anti-KCNK15 (TASK-5) (extracellular) Antibody (#APC-158) can be used in western blot analysis. The antibody recognizes an extracellular epitope and is thus ideal for detecting the channel in living cells. It has been designed to recognize KCNK15 from rat and mouse samples. The antibody will unlikely recognize the channel from human samples.