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Anti-KCNS2 (KV9.2) Antibody

Voltage-gated K+ channel subunit KV9.2

Cat #: APC-132
Alternative Name Voltage-gated K+ channel subunit KV9.2
Lyophilized Powder yes
Type: Polyclonal
Host: Rabbit
Reactivity: h, m, r
Immunogen
  • Peptide CDFGDGMKEVPSVNLR, corresponding to amino acid residues 430-445 of rat KV9.2 (Accession Q9ER26). Intracellular, C-terminus.
Accession (Uniprot) Number Q9ER26
Gene ID 66022
Peptide confirmation Confirmed by amino acid analysis and mass spectrometry.
Homology Mouse, human – identical.
Purity Affinity purified on immobilized antigen.
Form Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Isotype Rabbit IgG.
Storage before reconstitution The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Reconstitution 25 µl, 50 µl or 0.2 ml double distilled water (DDW), depending on the sample size.
Antibody concentration after reconstitution 0.8 mg/ml.
Storage after reconstitution The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Standard quality control of each lot Western blot analysis.
Applications: wb
May also work in: ic*, ifc*, ih*, ip*
Western blot
  • Western blot analysis of mouse brain lysate:
    Western blot analysis of mouse brain lysate:
    1. Anti-KCNS2 (KV9.2) Antibody (#APC-132), (1:200).
    2. Anti-KCNS2 (KV9.2) Antibody, preincubated with KCNS2/Kv9.2 Blocking Peptide (#BLP-PC132).
  • Western blot analysis of rat brain lysate:
    Western blot analysis of rat brain lysate:
    1. Anti-KCNS2 (KV9.2) Antibody (#APC-132), (1:200).
    2. Anti-KCNS2 (KV9.2) Antibody, preincubated with KCNS2/Kv9.2 Blocking Peptide (#BLP-PC132).
References
  1. Salina, M. et al. (1997) J. Biol. Chem. 272, 24371.
  2. Bocksteins, E. et al. (2016) J. Gen. Physiol. 147, 105.
Scientific background

KV9.2 is a member of the electrically silent voltage-gated K+ (KV). Ten KV silent subunits have been identified: KV5.1, KV6.1–KV6.4, KV8.1, KV8.2, and KV9.1–KV9.3. KV9.2 modulates the activity of KV2.1 and KV2.2 channels1,2. KV9.2 structure includes six transmembrane segments: S1–S6, positive residues on S4, the K+ signature sequence GYG on the pore loop between S5 and S6, and cytoplasmic N and C termini2.

High KV9.2 expression level can be found in the olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, and cerebellum1.

Application key:

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Species reactivity key:

H- Human, M- Mouse, R- Rat
Lyophilized Powder
Last update: 22/05/2022

Anti-KCNS2 (KV9.2) Antibody (#APC-132) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize KV9.2 channel from human, rat, and mouse samples.

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For research purposes only, not for human use
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