- Peptide (C)NTSLKLRKFDSLRR, corresponding to amino acid residues 118-131 of rat MMGT1 (Accession B5DF51). Intracellular, C-terminus.
- Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) heart lysates:1,2. Anti-MMGT1 Antibody (#ANT-149), (1:400).
3,4. Anti-MMGT1 Antibody, preincubated with MMGT1 Blocking Peptide (#BLP-NT149).
The MMgT gene family is comprised of two members: MMgT1 (membrane Mg2+ transporter 1) and MMgT2 (membrane Mg2+ transporter 2). Both proteins mediate Mg2+ uptake when expressed in Xenopus laevis oocytes. An increase in MMgT1 and MMgT2 transcripts is detected when there are low levels of Mg2+. There are two predicted transmembrane domains suggesting that the protein can form functional oligomers. It has been suggested that it may form homo- and, perhaps, heterooligomeric units.
MMgT1 can be found in the cell in golgi complex and post-golgi vesicles. The protein is expressed in a wide variety of tissues including in the liver and brain and more abundant expression in the heart muscle and kidney is observed. Very small amounts of transcripts are detected in the intestine and colon.
Species reactivity key:
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of rat membrane magnesium transporter 1. Anti-MMGT1 Antibody(#ANT-149) can be used in western blot analysis. It has been designed to recognize MMgT1 from mouse, rat and human samples.