- Peptide (C)GQSDDSTRK(S)TGEE, corresponding to amino acid residues 368-381 of rat mGluR6 (Accession P35349). Extracellular, N-terminus.
- Western blot analysis of rat eye lysates:1. Anti-mGluR6 (extracellular) Antibody (#AGC-026), (1:200).
2. Anti-mGluR6 (extracellular) Antibody, preincubated with mGluR6 (extracellular) Blocking Peptide (#BLP-GC026).
- Conn, P.J. et al. (2005) Nat. Rev. Neurosci. 6, 787.
- Costantino, G. (2006) Curr. Pharm. Des. 12, 2159.
- Ferraguti, F. and Shigemoto, R. (2006) Cell Tissue Res. 326, 483.
- Nakajima, Y. et al. (1993) J. Biol. Chem. 268, 11868.
- Nawy, S. (2000) J. Neurosci. 20, 4471.
- Foreman, M.A. et al. (2005) J. Cell Physiol. 204, 704.
Glutamate is the principal excitatory neurotransmitter in the central nervous system. It operates through two main classes of receptors: ionotropic receptors (iGluRs), which are ligand-gated ion channels, and metabotropic receptors (mGluRs), which couple to G-proteins to modulate cellular responses via ion channels or intracellular second messengers.
The metabotropic receptors include eight family members (mGluR1-mGluR8) classified into three groups according to their sequence similarities, signal transduction, and agonist selectivity. They all share a common structure, being composed of a single polypeptide with large N-terminal extracellular domain connected through a seven transmembrane domain motif to the intracellular C-terminal tail1,2. The different mGluR subtypes are localized at both presynaptic and postsynaptic membranes, and are involved in the generation of slow excitatory and inhibitory synaptic potentials, modulation of synaptic transmission, synaptic integration, and plasticity3.
mGluR6 belongs to the third group of metabotrophic glutamate receptors. Its expression in the central nervous system is restricted to retinal rod bipolar cells, and it’s localized to their postsynaptic dendritic membranes3,4. In the peripheral nervous system, it is also detected in bone marrow stromal cells6. mGluR6 inhibits adenylate cyclase, and was shown to inhibit Ca2+ influx and nitric oxide synthase activity3,5,6.
Species reactivity key:
Anti-mGluR6 (extracellular) Antibody (#AGC-026) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. The antibody recognizes an extracellular epitope and can potentially detect the receptor in living cells. It has been designed to recognize mGluR6 from rat, mouse, and human samples.
- Anti-mGluR1 (extracellular) Antibody (#AGC-006)
- Anti-mGluR2 (extracellular) Antibody (#AGC-011)
- Anti-mGluR3 (extracellular) Antibody (#AGC-012)
- Anti-mGluR4 (extracellular) Antibody (#AGC-014)
- Anti-mGluR5 (extracellular) Antibody (#AGC-007)
- Anti-mGluR7 (extracellular) Antibody (#AGC-017)
- Anti-mGluR8 (extracellular) Antibody (#AGC-028)