- Alomone Labs ATPA activates GluK1 (GluR5) kainate receptors expressed in Xenopus oocytes.Representative time course of GluK1 (GluR5) current, activated by a transient application of 1 µM ATPA (#A-480) at a holding potential of -80 mV.
ATPA, an AMPA derivative, is a potent and selective agonist of the GluR5 (GluK1) kainate receptor subtype, with an EC50 value of 0.66 µM1. ATPA is less active towards other kainate receptor subtypes and is inactive towards GluR6. The compound also shows weak agonistic activities towards AMPA receptors1,2. Studies show that ATPA can induce clonic seizures when infused intravenously or directly into the rat amygdala3.
GluR5 containing kainate receptors play an important role in the regulation of GABA(A) receptor-mediated inhibitory transmission in the hippocampus and in the amygdala3.
ATPA (#A-480) is a highly pure, synthetic, and biologically active compound.