Ceratotoxin-2

β-Theraphotoxin-Cm1b, β-TRTX-Cm1b, CcoTx2
A Potent Blocker of Central Nervous System Voltage-Gated Na+ Channels
    Cat #: STC-100
    Alternative Name β-Theraphotoxin-Cm1b, β-TRTX-Cm1b, CcoTx2
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 4093 Da.
    Purity: >98% (HPLC)
    Effective concentration 5 nM - 2 µM.
    Sequence DCLGWFKSCDPKNDKCCKNYTCSRRDRWCKYYL.
    Modifications Disulfide bonds between Cys2-Cys17, Cys9-Cys22, Cys16-Cys29. Leu33 - C-terminal amidation.
      • Ceratotoxin-2
    Molecular formula C177H260N52O49S6.
    Activity Ceratotoxin-2 modulates different voltage-gated Na+ channel subtypes from the central nervous system (NaV1.1-NaV1.5 and NaV1.8) by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the Na+ current. It is significantly more potent against the NaV1.2 channel than other NaV channel subtypes1.
      • Bosmans, F. et al. (2006) Mol. Pharmacol.  69, 419.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
      • Ceratotoxin-2
        Alomone Labs Ceratotoxin-2 inhibits NaV1.2 channels heterologously expressed in Xenopus oocytes.
        NaV1.2 currents were elicited by application of voltage step of 100 ms from -80 mV (holding potential) to 10 mV. A. Time course of channel activity (peak current amplitude) before (black) and during (green) application of 200 nM Ceratotoxin-2 (#STC-100). B. Example of superimposed current traces before (black) and during (green) application of the toxin, taken from the experiment in A.
    References - Scientific background
    • 1. Bosmans, F. et al. (2006) Mol. Pharmacol.  69, 419.
      • Ceratotoxin-2 was originally isolated from the Ceratogyrus cornuatus (Ceratogyrus marshalli, Straighthorned baboon tarantula) venom1.

        Ceratotoxin-2 modulates different voltage-gated Na+ channel subtypes from the central nervous system by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the Na+ current. It is significantly more potent against NaV1.2 channel than the other NaV channel subtypes1.

    Target NaV channels
    Net Peptide Content: 100%
    Last update: 24/01/2020

    Ceratotoxin-2 (#STC-100) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use