This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Bosmans, F. et al. (2006) Mol. Pharmacol. 69, 419.
- Alomone Labs Ceratotoxin-2 inhibits NaV1.2 channels heterologously expressed in Xenopus oocytes.NaV1.2 currents were elicited by application of voltage step of 100 ms from -80 mV (holding potential) to 10 mV. A. Time course of channel activity (peak current amplitude) before (black) and during (green) application of 200 nM Ceratotoxin-2 (#STC-100). B. Example of superimposed current traces before (black) and during (green) application of the toxin, taken from the experiment in A.
- 1. Bosmans, F. et al. (2006) Mol. Pharmacol. 69, 419.
Ceratotoxin-2 was originally isolated from the Ceratogyrus cornuatus (Ceratogyrus marshalli, Straighthorned baboon tarantula) venom1.
Ceratotoxin-2 modulates different voltage-gated Na+ channel subtypes from the central nervous system by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the Na+ current. It is significantly more potent against NaV1.2 channel than the other NaV channel subtypes1.
Ceratotoxin-2 (#STC-100) is a highly pure, synthetic, and biologically active peptide toxin.