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Cl-HIBO

4-Chlorohomoibotenic acid

An Agonist of AMPA Receptors

Cat #: C-355
Alternative Name 4-Chlorohomoibotenic acid
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 206.58
    Purity: >99% (HPLC)
    Effective concentration 0.1-100 µM.
    Structure
    Chemical name 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid.
    Molecular formula C6H7ClN2O4.
    CAS No.: 909400-43-7
    PubChem CID 4694356
    Activity Cl-HIBO is an AMPA receptor agonist, highly selective for GluR1 and GluR2 subunit-containing receptors (EC50 for rat recombinant homomeric GluR1, 2, 3 and 4 receptors are 4.7, 1.7, 2700 and 1300 μM, respectively)1.
    References-Activity
    1. Bjerrum, E.J. et al. (2003) J. Med. Chem. 46, 2246.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up to 20 mM in H2O (slow). Centrifuge all products before reconstitution (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.
    Our bioassay
    • Alomone Labs Cl-HIBO activates GluA1 receptors expressed in Xenopus oocytes. 
      Alomone Labs Cl-HIBO activates GluA1 receptors expressed in Xenopus oocytes. 
      Time course of current, reversibly activated by 1 µM, 10 µM and 100 µM Cl-HIBO (#C-355), as indicated, while membrane potential was held at -60 mV.
    References - Scientific background
    1. Bjerrum, E.J. et al. (2003) J. Med. Chem. 46, 2246.
    2. Guntupalli, S. et al. (2016) Neural Plast. 2016, 3204519.
    Scientific background

    Cl-HIBO (chloro-homoibotenic acid) acts as a full agonist at AMPA receptors (AMPARs). Cl-HIBO is the most selective agonist reported to-date for GluR1/2. Thus, the compound is considered to be a valuable tool for studying the biological behavior and distribution of AMPARs1.

    The ionotropic glutamate AMPA receptors are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane2.

    Target AMPA receptors
    Last update: 11/04/2021

    Cl-HIBO (#C-355) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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