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Conantokin G

Con-G, CGX-1007, Conotoxin GV, Sleeper peptide

A Selective and Competitive Antagonist of GluN2B Receptor

Cat #: STC-666
Alternative Name Con-G, CGX-1007, Conotoxin GV, Sleeper peptide
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 2264.2 Da
    Purity: >98% (HPLC)
    Form Lyophilized powder.
    Effective concentration 500 nM.
    Sequence GEXXLQXNQXLIRXKSN.
    Modifications X=4-Carboxyglutamate, C-terminal amidation at Asp17.
    Structure
    Molecular formula C88H138N26O44.
    CAS No.: 93438-65-4
    Activity ConantokinG is a GluN2B competitive antagonist1.
    References-Activity
    1. Balsara, R. et al. (2012) Neuropharmacology 62, 2227.
    Accession number P07231.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all products preparations before use (1000 X g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Conantokin G efficiently inhibits NMDA receptors expressed in Xenopus oocytes.
      Alomone Labs Conantokin G efficiently inhibits NMDA receptors expressed in Xenopus oocytes.
      Representative NR1A/NR2B current elicited in Mg2+-free bath solution by continuous co-application of 1 µM glutamate and 100 µM glycine (black bar), and fully inhibited by 50 µM Conantokin G (#STC-666) application (red bar). Membrane potential was held at -60 mV and current was recorded by two-electrode voltage-clamp.
      The figure was kindly provided by Prof. Shai Berlin, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel.
    References - Scientific background
    1. Reyes-Guzman, E.A. et al. (2017) BMC Neurosci. 18, 44.
    2. Balsara, R. et al. (2015) PLoS One 10, e0122840.
    3. Balsara, R. et al. (2012) Neuropharmacology 62, 2227.
    Scientific background

    Conantokin G is a 17 amino acid peptide toxin originally isolated from Conus geographus venom. The toxin acts as a selective antagonist of the GluN2B, a subunit of NMDA receptors1-3. Conantokin G structure includes γ-carboxiglutamic acid which coordinates binding of 4 calcium ions1,2.

    Conantokin G has IC50 values of 0.48 µM in hippocampal and cortical neurons, and 0.1 µM in Xenopus oocytes expressing the GluN1–GluN2B subunits1. In vitro studies of neuronal cultures have revealed anti-apoptotic properties of Conantokin G. In animal models, Conantokin G has been successfully tested as an anti-convulsant and as an anti-analgesic agent.

    NMDA receptors belong to the family of ionotropic receptors coactivated by glutamate and glycine. They play a central role in neuronal plasticity, learning, and memory3.

    Target GluN2B receptor
    Peptide Content: 100%
    Lyophilized Powder
    Last update: 08/06/2021

    Conantokin G (#STC-666) is a highly pure, synthetic, and biologically active peptide toxin.

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    For research purposes only, not for human use
    Shipping and Ordering information

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