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[D-Ala7]-Angiotensin I/II (1-7)

A-779

A Potent Agonist of AT1R and Antagonist of Angiotensin-(1-7) Mas Receptor

Cat #: SPA-160
Alternative Name A-779
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 873 Da
    Purity: ≥98% (HPLC)
    Effective concentration 1-200 µM.
    Sequence DRVYIHa.
    Modifications Ala-7 = D-Ala.
    Structure
    Molecular formula C39H60N12O11.
    CAS No.: 159432-28-7
    Activity An Angiotensin (1-7) Antagonist1.
    References-Activity
    1. Santos, R.A. et al. (1994) Brain Res. Bull. 35, 293.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs [D-Ala7]-Angiotensin I/II (1-7) increases the activation of Angiotensin AT1R expressed in CHO-K1-mt Aequorin-Gα16 cells.
      Alomone Labs [D-Ala7]-Angiotensin I/II (1-7) increases the activation of Angiotensin AT1R expressed in CHO-K1-mt Aequorin-Gα16 cells.
      Ca2+ response, as detected by elevation in aequorin derived fluorescence, in response to increased concentration of [D-Ala7]-Angiotensin I/II (1-7) (#SPA-160), compared to 0.04 nM Angiotensin II. 20 µM [D-Ala7]-Angiotensin I/II (1-7) application resulted in ~65% activation of AT1R, equal to Angiotensin II response.
    References - Scientific background
    1. Benter, I.F. et al. (2011) J. Cardiovasc. Pharmacol. 57, 559.
    2. Santos, R.A. et al. (1994) Brain Res. Bull. 35, 293.
    3. Ambühl, P. et al. (1994) Brain Res. Bull. 35, 289.
    Scientific background

    D-Ala7-Angiotensin I/II (1-7) [D-Ala7-Ang-(1–7)] is a potent and selective synthetic Angiotensin (1-7) Mas receptor antagonist. It has the ability to antagonize several actions of Ang-(1-7), including the antidiuretic effect of the peptide. In addition, it antagonizes the effects of the changes in mean arterial pressure produced by Ang-(1-7) microinjection into the dorsomedial and ventrolateral medulla1-3.

    Ang-(1-7) is an alternative peptide, a product of the renin-angiotensin system (RAS), with special importance in modulating cell-to-cell communication in cardiovascular and neuronal tissue and plays a role in lowering blood pressure and can decrease the sympathetic nervous system activity.

    Ang-(1-7) is formed from Ang I by endopeptidases (neprilysin and prolyl oligopeptidase) or by Ang II by carboxypeptidases such as angiotensin-converting enzyme1,2.

    Target AT1, Angiotensin-(1-7) Mas receptors
    Peptide Content: 100%
    Lyophilized Powder
    Last update: 02/01/2022

    [D-Ala7]-Angiotensin I/II (1-7) (#SPA-160) is a highly pure, synthetic, and biologically active peptide.

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    For research purposes only, not for human use
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