Free shipping starts now, no minimum, no coupons required!

Galanin (2-11)

AR-M1896, Gal (2-11) amide

A Selective and Potent Agonist of Galanin 2/3 Receptors

Cat #: GPG-150
Alternative Name AR-M1896, Gal (2-11) amide
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1136 Da
    Purity: ≥98% (HPLC)
    Effective concentration 0.1-10 nM.
    Sequence WTLNSAGYLL.
    Modifications Leu10 - C-terminal amidation.
    Structure
    Molecular formula C54H81N13O14.
    CAS No.: 367518-31-8
    Activity A Galanin 2/3 receptor agonist1.
    References-Activity
    1. Lu, X. et al. (2005) Neuropeptides 39, 143.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Galanin (2-11) activates Galanin 2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt Aequorin cells.
      Alomone Labs Galanin (2-11) activates Galanin 2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt Aequorin cells.
      Dose response of normalized activation of the Galanin 2 receptor-mediated Ca2+ mobilization, evoked by Galanin (2-11) (#GPG-150). Ca2+ response was detected by measuring aequorin-derived fluorescence following application of Galanin (2-11) at different concentrations. The EC50 measured for Galanin (2-11) is 0.81 nM.
    References - Scientific background
    1. Liu, M. et al. (2013) PLoS One 8, e63473.
    2. Schmidt W.E. et al. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 11435.
    3. Zhang, M.L. et al. (2017) Sci. Rep. 7, 45930.
    Scientific background

    Galanin (2-11) is a neuropeptide that acts as a selective potent galanin 2 and 3 receptor (GalR2/3) agonist. Galanin is a C-terminally amidated 29-residue peptide deriving its name from the N-terminal glycine and C-terminal alanine residue. In humans the peptide contains additional nonamidated serine residue at C terminus. Galanin was firstly isolated from porcine intestine and shown to be widely distributed through the central and peripheral nervous system1-3.

    Its biological activity includes contraction or relaxation of gut smooth muscles, inhibition of insulin and somatostatin release, and modulation of hormone secretion from the pituitary and adrenal gland. It is believed that galanin plays an important role as a neuromodulator of endocrine secretion and synaptic transmission1.

    Galanin receptors belong to the family of G-protein coupled receptors and consist of three subtypes: GalR1, GalR2, and GalR3. Additional studies show that galanin and its receptors are involved in the transmission and modulation of nociception2.

    Target Galanin 2/3 receptors
    Peptide Content: 100%
    Last update: 06/11/2022

    Galanin (2-11) (#GPG-150) is a highly pure, synthetic, and biologically active peptide.

    For research purposes only, not for human use
    Shipping and Ordering information