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human, rat Spexin-1

NPQ, Neuropeptide Q, Spexin hormone, NPQ 53-70

A Potent Agonist of Galanin 2 and Galanin 3 Receptors

Cat #: SPS-100
Alternative Name NPQ, Neuropeptide Q, Spexin hormone, NPQ 53-70
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1620 Da
    Purity: ≥98% (HPLC)
    Effective concentration 20-50 nM.
    Sequence NWTPQAMLYLKGAQ.
    Modifications Gln14 - C-terminal amidation.
    Structure
    Molecular formula C74H114N20O19S.
    CAS No.: 1370290-58-6
    Activity Spexin-1 is a Galanin 2 and Galanin 3 receptor agonist1.
    References-Activity
    1. Reyes-Alcaraz A. et al. (2016) Sci. Rep. 6, 21453.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs human, rat Spexin-1 activates Galanin 2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt Aequorin cells.
      Alomone Labs human, rat Spexin-1 activates Galanin 2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt Aequorin cells.
      Dose-response of normalized activation of the Galanin 2 receptor-mediated Ca2+ mobilization, evoked by human, rat Spexin-1 (#SPS-100). Ca2+ response was detected by measuring aequorin-derived fluorescence following application of human, rat Spexin-1 at different concentrations. The EC50 measured for human, rat Spexin-1 is 21.04 nM.
    References - Scientific background
    1. Reyes-Alcaraz A. et al. (2016) Sci. Rep. 6, 21453.
    2. Lin, C.Y. et al. (2015) Sci. Rep. 5, 12095.
    Scientific background

    Spexin-1 is a potent 14 amino acid neuropeptide that acts as a Galanin 2 (GALR2) and Galanin 3 (GALR3) receptor agonist, and shows no activity towards Galanin receptor 1.

    Expression of spexin-1 at the mRNA and protein levels are detected in the brain and in peripheral tissues of humans, mice and rats. Studies have shown that and administration of Spexin-1 leads to weight loss in rodents and suppresses appetite in goldfish1.

    GalR2 and GalR3 receptors are implicated in several biological functions, in which the central nervous system functions controlling memory, seizure, pain, anxiety, depression, and mood disorder2.

    Target Galanin 2, Galanin 3 receptors
    Peptide Content: 100%
    Last update: 06/11/2022

    human, rat Spexin-1 (#SPS-100) is a highly pure, synthetic, and biologically active peptide.

    For research purposes only, not for human use
    Shipping and Ordering information